Changes in microchip position after implantation of a subretinal vision prosthesis in humans

Acta Ophthalmologica
Laura KuehleweinKatarina Stingl

Abstract

Retinal prosthetic devices have been developed to partially restore very low vision in legally blind patients with end-stage hereditary retinal dystrophies. Subretinal implants, unlike epiretinal implants, are not fixated by a tack. The aim of this study was to assess and analyse possible changes over time in the subretinal position of the RETINA IMPLANT Alpha IMS and Alpha AMS (ClinicalTrials.gov NCT01024803). Imaging studies were performed on fundus photographs using GIMP (Version 2.8.14). Postoperative photographs of the implanted eye were scaled and aligned. Landmarks were chosen and distances between landmarks were measured to then calculate the displacement of the microchip using a transformation matrix for rotational and translational movements. Analyses were performed using MATLAB 8.6 (The MathWorks Inc., Natick, MA). Of the 27 datasets with the Alpha IMS device, 12 (44%) remained stable without displacement of the microchip relative to the optic disc and the major blood vessels, whereas in 15 (56%), displacement occurred. The mean ± SD displacement in those 15 eyes was 0.66 ± 0.35 mm (range, 0.24-1.67 mm). Of the eight datasets with the Alpha AMS device, 1 (13%) remained stable without displacement of the microchip rel...Continue Reading

References

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Feb 16, 2013·Current Eye Research·Katarina StinglFaik Gelisken
Feb 22, 2013·Proceedings. Biological Sciences·Katarina StinglEberhart Zrenner
Oct 24, 2013·Investigative Ophthalmology & Visual Science·Katarina StinglEberhart Zrenner
Nov 8, 2013·Science Translational Medicine·Eberhart Zrenner
Mar 31, 2015·Vision Research·Katarina StinglEberhart Zrenner
Sep 24, 2015·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alex E HadjinicolaouMichael R Ibbotson
Sep 25, 2016·Ophthalmology·Mark S HumayunGislin Dagnelie
Jan 27, 2017·Biomedical Microdevices·Renate DaschnerWalter G Wrobel
Dec 19, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Laura KuehleweinKatarina Stingl

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Citations

Apr 19, 2020·Acta Ophthalmologica·Hanna FaberKatarina Stingl
Jul 24, 2020·Current Ophthalmology Reports·Victor Wang, Ajay E Kuriyan
Jul 30, 2019·Progress in Retinal and Eye Research·Rebecca L PfeifferBryan William Jones

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