Abstract
Changes in matrix metalloproteinase (MMP)-2, MMP-9, inflammation, blood coagulation factors and intestinal mucosal permeability in patients with active ulcerative colitis (UC) were investigated. A total of 50 active UC patients treated in our hospital from January 2016 to December 2018 were selected as the UC group, whereas 50 normal subjects receiving physical examination were selected as the control group. Venous blood was drawn to detect the content of early predictors, C-reactive protein (CRP), follistatin-like protein 1 (FSTL1) and D-dimer in serum. The disease activity index (DAI) score was recorded in both groups, the levels of MMP-2 and MMP-9 were determined, and the inflammatory factors interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α were also detected. Moreover, the blood coagulation factors, platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen level were detected, the content of lactulose (L) and mannitol (M) in the urine after oral administration of L and M test liquid was determined via high-performance liquid chromatography in both groups, and the L/M ratio was calculated. In UC group, the content of CRP, FSTL1 and D-dimer was significantly higher than that ...Continue Reading
References
Jun 19, 2003·The Journal of Trauma·Karim BrohiTimothy Coats
Sep 10, 2005·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Mark S SilverbergB F Warren
Jan 24, 2007·Inflammatory Bowel Diseases·Qiang GaoHein W Verspaget
Feb 8, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Mattias SoopOlle Ljungqvist
Jun 28, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ireneusz M SalataAndrzej Lewiński
Aug 12, 2009·The Journal of Trauma·Myung S ParkJohn B Holcomb
Nov 20, 2009·The New England Journal of Medicine·Clara Abraham, Judy H Cho
Apr 5, 2012·British Journal of Cancer·A M J LangersC F M Sier
Apr 6, 2012·PloS One·Angelina E AltshulerGeert W Schmid-Schönbein
Aug 24, 2012·Lancet·Daniel C Baumgart, William J Sandborn
Aug 24, 2012·Lancet·Ingrid OrdásWilliam J Sandborn
Nov 16, 2014·Journal of Cancer Research and Clinical Oncology·Huili LuAnja Moldenhauer
Dec 3, 2014·The International Journal of Biochemistry & Cell Biology·Sajid KhanSyed Musthapa Meeran
Dec 4, 2014·Cell Reports·Emmanuelle GodefroyNina Bhardwaj
Dec 23, 2014·Hormone Research in Pædiatrics·Avril MasonS Faisal Ahmed
Feb 6, 2015·Inflammation·Wu-Li LiShou-Liang Zhao
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Apr 2, 2016·Gastroenterology Research and Practice·Katarzyna JakubowskaKatarzyna Guzińska-Ustymowicz
May 10, 2016·Nature Medicine·Bruno LamasHarry Sokol
Jul 20, 2016·Disease Markers·Katarzyna JakubowskaKatarzyna Guzińska-Ustymowicz
May 16, 2017·Lancet·Kristin K JørgensenUNKNOWN NOR-SWITCH study group
Sep 21, 2017·Oncology Letters·Juan WangYuanling Qi
Dec 20, 2017·Journal of Clinical Gastroenterology·Joany E KreijneGwenny M Fuhler
Aug 21, 2018·The Lancet. Gastroenterology & Hepatology·Nghia H NguyenSiddharth Singh
Sep 20, 2018·European Review for Medical and Pharmacological Sciences·P-L Sun, S Zhang
Aug 9, 2019·Medicine·Chimezie MbachiVikram Kotwal
Citations
Oct 2, 2020·International Journal of Radiation Oncology, Biology, Physics·Laura E EwingIgor Koturbash
Feb 18, 2021·Innate Immunity·Cuijuan ZhengShouxiang Xie
Jun 15, 2021·Saudi Journal of Biological Sciences·Areej A Eskandrani
Jun 10, 2021·American Journal of Hypertension·Yang JingChen Dong