PMID: 2508750Nov 2, 1989Paper

Changes in mRNA levels of poly(ADP-ribose) polymerase during activation of human lymphocytes

Biochimica Et Biophysica Acta
R McNerneyA P Johnstone

Abstract

The level of mRNA encoding the nuclear enzyme poly(ADP-ribose) polymerase (ADP-ribosyltransferase, EC 2.4.2.30) was found to be very low in quiescent human lymphocytes and to increase at least 10-fold between 1 and 2 dyas after stimulation with the mitogen phytohaemagglutinin, staying high for several days thereafter. This increase was inhibited by 3-methoxybenzamide (a competitive inhibitor of poly(ADP-ribose) polymerase) but was not affected significantly by aphidicolin. Incubation of activated cells with cycloheximide for 2 h increased the expression slightly. These data demonstrate that, during lymphocyte activation, the level of mRNA of the poly(ADP-ribose) polymerase gene correlates with, and hence is presumably responsible for, the increase in poly(ADP-ribose) polymerase protein detectable by enzyme assay or immunochemistry.

References

May 11, 1989·Nucleic Acids Research·K HuppiM Smulson
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Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C ReedR G Hoover
Oct 29, 1987·Biochemical and Biophysical Research Communications·K UchidaT Sugimura
Sep 1, 1983·Bioscience Reports·G T Williams, A P Johnstone

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Citations

Sep 1, 1994·Molecular and Cellular Biochemistry·J LagueuxG G Poirier
May 26, 1993·Molecular and Cellular Biochemistry·D LautierG G Poirier
May 1, 1993·Biological Reviews of the Cambridge Philosophical Society·T Alderson
Feb 3, 2004·American Journal of Respiratory Cell and Molecular Biology·Robert ErtseyLouis M Scavo
Sep 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G de MurciaV Schreiber
Feb 24, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Leonardo CavoneAlberto Chiarugi
Mar 4, 2005·American Journal of Physiology. Cell Physiology·Takuya KitamuraYoshimi Homma
Dec 1, 2010·Social and Personality Psychology Compass·Baruch Eitam, E Tory Higgins
Mar 23, 2019·Cognitive Science·Sara FarshchiCarita Paradis
Apr 15, 2014·British Journal of Pharmacology·L CavoneA Chiarugi
May 28, 1993·Biochimica Et Biophysica Acta·M Negroni, U Bertazzoni
Oct 23, 1990·Biochimica Et Biophysica Acta·C F CesaroneU Bertazzoni

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