PMID: 8947474Nov 15, 1996Paper

Changes in mRNA levels of the sarcoplasmic/endoplasmic-reticulum Ca(2+)-ATPase isoforms in the rat soleus muscle regenerating from notexin-induced necrosis

The Biochemical Journal
E ZádorF Wuytack

Abstract

The relative mRNA levels corresponding to the different sarcoplasmic/endoplasmic-reticulum Ca(2+)-ATPase isoforms (SERCA1a, SERCA1b, SERCA2a, SERCA2b and SERCA3) were measured by reverse transcriptase-PCR in rat soleus muscles regenerating after notexin-induced necrosis. The succession of appearance of the different types of SERCA mRNA species in regenerating muscle largely recapitulates those observed during normal ontogenesis. The mRNA levels of the muscle-specific isoforms SERCA1a and SERCA2a became very low on the first and third days after injection of the snake venom. It was only on the fifth day of regeneration that the mRNA of the neonatal variant of the fast-twitch skeletal SERCA1b isoform began to rise, well before the other SERCA transcripts. At 7 and 10 days, i.e. at a time when the new myofibres normally become reinnervated, the mRNA level of SERCA1a and SERCA2a increased markedly, but the fast-twitch skeletal SERCA1a isoform was still the most prominent. On day 21, in the advanced stage of regeneration, a switch in the relative expression levels of SERCA1a and SERCA2a mRNA was observed and the ratio of both isoforms became similar to that found in the normal soleus muscles. This was followed by a decline in the le...Continue Reading

Citations

Aug 6, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·András SzabóErno Zádor
Dec 2, 2010·Histochemistry and Cell Biology·Erno ZádorFrank Wuytack
May 15, 2012·Molecular Biotechnology·Magdolna Kósa, Ernő Zádor
Apr 9, 2001·Antioxidants & Redox Signaling·T PatakiA Tosaki
May 30, 2003·American Journal of Physiology. Cell Physiology·Erno Zádor, Frank Wuytack
Dec 18, 2014·Pflügers Archiv : European journal of physiology·Ernő Zádor, Magdolna Kósa
Dec 10, 2014·Journal of Muscle Research and Cell Motility·Magdolna KósaErnő Zádor
Apr 25, 2012·Cell Transplantation·Iwona GrabowskaMaria A Ciemerych
Oct 17, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Luca MendlerLászló Dux
Apr 13, 1999·The American Journal of Physiology·T A Reinhardt, R L Horst
Aug 12, 1999·Free Radical Biology & Medicine·C CsonkaA Tosaki
Nov 26, 1999·Life Sciences·L Van Den BoschW Robberecht
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·J B Harris
Jun 29, 2004·Biochemical and Biophysical Research Communications·Rita FenyvesiErno Zádor

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