Changes in myocardial blood volume over a wide range of coronary driving pressures: role of capillaries beyond the autoregulatory range

Heart
D Elizabeth LeS Kaul

Abstract

To determine whether, when the vasomotor capacity of the coronary arterioles is exhausted at rest, myocardial blood volume decreases in order to maintain a normal capillary hydrostatic pressure, even at the expense of myocardial oxygen delivery. 18 dogs were studied. In group 1 (n = 9), coronary driving pressure (CDP) was reduced by 10-80 mm Hg below normal by a stenosis; in group 2 (n = 9), it was increased 20-80 mm Hg above baseline by increasing aortic pressure with phenylephrine. Myocardial contrast echocardiography (MCE) was undertaken to measure the myocardial blood volume fraction and myocardial blood flow (MBF). In group 1 dogs, as CDP was reduced, both coronary blood flow (CBF) and MBF decreased. Myocardial blood volume fraction also decreased and myocardial vascular resistance increased, while coronary sinus PO2 decreased. In group 2 dogs, as CDP was increased, epicardial CBF increased but MBF remained unchanged because of a decrease in myocardial blood volume fraction. Myocardial vascular resistance decreased, however, implying the presence of coronary arteriovenous shunting, which was supported by a progressive increase in the coronary sinus PO2. When arteriolar tone is exhausted so that CBF becomes dependent on CDP...Continue Reading

References

Jan 1, 1979·Microvascular Research·H F DowneyP E Parker
Jun 1, 1989·Journal of Cardiothoracic Anesthesia·A Sidi, R F Davis
Jul 1, 1974·The American Journal of Cardiology·K L Gould, K Lipscomb
Mar 1, 1993·Circulation Research·L KuoM J Davis
Dec 1, 1995·Journal of Molecular and Cellular Cardiology·B J FriedmanH M Swartz
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Dana DawsonJonathan R Lindner

❮ Previous
Next ❯

Citations

Apr 7, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sanjiv Kaul
Jun 12, 2013·Nature Reviews. Cardiology·Tim P van de HoefJan J Piek
Feb 27, 2009·British Journal of Anaesthesia·S MaierH Knotzer
May 21, 2008·Current Cardiology Reports·Chad L Carr, Jonathan R Lindner
Jan 15, 2014·Magnetic Resonance Imaging·Octavia BaneTimothy J Carroll
Nov 1, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Feng XieThomas R Porter
Feb 2, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·N SiegenthalerK Bendjelid
May 15, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·John J PacellaFlordeliza S Villanueva
Apr 19, 2013·International Journal of Experimental Pathology·Flávia R R MazzoMarcia K Koike
Apr 4, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Siri MalmTerje Skjarpe
Sep 29, 2015·Korean Circulation Journal·Sanjiv Kaul
Feb 18, 2010·JACC. Cardiovascular Imaging·Sanjiv Kaul
Jul 31, 2016·The International Journal of Cardiovascular Imaging·Dirkjan KuijpersMatthijs Oudkerk
Sep 4, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Carolien S E BulteR Arthur Bouwman
Apr 10, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sanjiv KaulKevin Wei
Nov 19, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Nicola GaibazziClaudio Reverberi
Dec 15, 2017·European Heart Journal·Guus A de WaardJustin E Davies
Feb 2, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Samuel S ShinMisun Hwang
Jan 25, 2006·Circulation·Jos A E SpaanMaria Siebes
May 2, 2015·Circulation Research·Michael SimonsUNKNOWN American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular Surgery and Anesthesia
Jul 7, 2005·Circulation·Roldano ScognamiglioAngelo Avogaro
May 26, 2009·Cardiovascular Engineering·Adam BlackLawrence Mulligan
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Stefano F de MarchiChristian Seiler
Oct 30, 2018·Pflügers Archiv : European journal of physiology·Richard J MarszalekBeata M Wolska
Jun 9, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Federica E PoliMatthew Pm Graham-Brown
Sep 13, 2020·Diagnostics·Muhammad Talha Ayub, Dinesh Kalra
Oct 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Carmen MethnerSanjiv Kaul

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.