PMID: 9192213Jan 1, 1997Paper

Changes in natural killer cell subpopulations in lead workers

International Archives of Occupational and Environmental Health
F SataN Katsuno

Abstract

To investigate the effects of lead on human immune system, we analyzed T cell subpopulations (CD4+, CD8+ and CD3+ cells), natural killer (NK) cell subpopulations (CD16+ and CD57+ cells) and B (CD19+) cells in peripheral blood in 29 male lead workers. All were engaged in manufacturing lead stearate in a chemical factory. They were aged 23-74 (mean 49) years. Their blood lead concentrations (PbB) were between 7 and 35 (mean 18) micrograms/dl. They were divided into two groups according to their PbB: a high-PbB group (> or = 20 micrograms/dl), and a low-PbB group (< 20 micrograms/dl). The control group consisted of 19 "healthy" male workers without a history of occupational exposure to lead or to other hazardous substances, aged 48-67 (mean 58) years. The number and percentage of CD16+ cells in the high-PbB group were significantly lower than those in the controls and in the low-PbB group. There was significant negative correlation between the number of CD16+ cells and PbB in the lead workers. The percentage of CD8+ cells in the high-PbB group was larger than that in the controls and in the low-PbB group. It is suggested that the CD16+ NK cell should be a major site of the effects of lead on lymphocyte subpopulations.

Citations

Aug 31, 1999·Immunopharmacology and Immunotoxicology·B YücesoyA Karakaya
Jun 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K P Mishra
Dec 26, 2006·International Journal of Hygiene and Environmental Health·M SchwenkR Klein
Feb 19, 1998·Environmental Research·F SataN Katsuno
Apr 13, 2013·Journal of Korean Medical Science·Ja Hyeong KimYangho Kim
Feb 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·John B CareyFrank N van Pelt
Aug 5, 2020·Biological Trace Element Research·Taru GoyalPraveen Sharma
Mar 11, 2021·Archives of Environmental & Occupational Health·Jianrui DouFeng Zhang

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