PMID: 7541167May 1, 1995Paper

Changes in neuroendocrine elements in bronchial mucosa in chronic lung disease in adults

Thorax
M PilmaneF Sundler

Abstract

It is not clear whether there is any association between metaplasia of the bronchial epithelium and changes in the distribution of neuroendocrine cells. This study examined, by immunohistological techniques, the distribution of neuroendocrine cells and juxtamucoscal nerve fibres in bronchial biopsies showing metaplastic changes. Bronchial biopsies from 12 subjects with epithelial metaplasia associated with bronchiectasis and diffuse pulmonary fibrosis were examined by conventional light microscopy and immunohistological techniques for protein gene product 9.5 (PGP), chromogranin A and B (CAB), serotonin, vasoactive intestinal peptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP), calcitonin (CT), and gastrin releasing peptide (GRP). Regions of non-metaplastic epithelium contained numerous PGP and serotonin immunoreactive cells. Sub-populations of these cells displayed CAB, CGRP, CT, and GRP immunoreactivity. Metaplastic epithelium contained only a few weakly stained PGP, serotonin, CAB, GRP, CT and CGRP immunoreactive cells in six cases. Metaplastic epithelium was characterised by a high number of CAB-containing cells in six cases and in these biopsies prominent PGP-containing nerve bundles were seen in the su...Continue Reading

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Citations

Feb 3, 1999·Annals of the New York Academy of Sciences·M PilmaneT P Iismaa
May 3, 2011·Polish Journal of Veterinary Sciences·A Valdovska, M Pilmane
Mar 27, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Y Fang, C L Shen
Jul 9, 1998·Acta Oto-laryngologica·S Y FangM Ohyama
Apr 24, 2015·American Journal of Respiratory and Critical Care Medicine·Peter W WestJaclyn A Smith
Jan 30, 2015·Journal of Materials Science. Materials in Medicine·Jolanta VamzeAndrejs Skagers
Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Luisella RighiMauro Papotti
Apr 15, 2014·Polish Journal of Veterinary Sciences·A ValdovskaM Lazdins
Aug 8, 2018·Respiratory Research·Kalina R Atanasova, Leah R Reznikov
Aug 17, 2021·Acta Medica Lituanica·Olga Rimdenoka, Māra Pilmane

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