Changes in neutrophil/lymphocyte and platelet/lymphocyte ratios after chemotherapy correlate with chemotherapy response and prediction of prognosis in patients with unresectable gastric cancer

Oncology Letters
Fen WangWei Li

Abstract

The aim of the study was to investigate the application value of neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) in the prediction of chemotherapy response and prognosis in patients with advanced gastric cancer. In total, 120 patients with unresectable gastric cancer were included and separated into two groups according to the median values of NLR or PLR (NLR low: <4.62 or NLR high: ≥4.62 and PLR low: <235 or PLR high: ≥235, respectively). Low baseline NLR level correlated with improved clinicopathological characteristics, including smaller tumor size, well differentiation and less metastasis. Low baseline PLR level also associated with less metastasis. Patients with a low baseline level of NLR or PLR had an improved response to chemotherapy. Patients with a higher baseline NLR and PLR had decreased progression-free survival (PFS) and overall survival (OS) ratios. Alterations in the NLR and PLR levels were associated with therapeutic efficacy and prognosis. The patients who remained in or switched to the low NLR level subgroup subsequent to first-line chemotherapy had an improved response and improved OS ratios, compared to the patients remaining in or switching to the high NLR level group. Simil...Continue Reading

References

May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Gennaro GaliziaCarlo Pignatelli
Aug 3, 2002·The British Journal of Surgery·T PopielaUNKNOWN Polish Gastric Cancer Study Group
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matthias H F Klinger, Wolfgang Jelkmann
Jan 9, 2003·Lancet·David FormanJos Kleijnen
Apr 26, 2003·American Journal of Clinical Oncology·Michael G AlexandrakisDespina S Kyriakou
Dec 5, 2003·Journal of the National Cancer Institute·Wei Hong WangBenjamin Chun-Yu Wong
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph E De LarcoLeo T Furcht
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Jun 6, 2006·Cytokine & Growth Factor Reviews·Dimitris TousoulisChristodoulos Stefanadis
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shashank JainJerry Ware
Sep 26, 2007·International Journal of Cancer. Journal International Du Cancer·S Perwez Hussain, Curtis C Harris
Feb 13, 2008·British Medical Bulletin·Paul Lochhead, Emad M El-Omar
Mar 1, 2008·The Lancet Oncology·Wai K LeungUNKNOWN Asia Pacific Working Group on Gastric Cancer
Oct 14, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C P NealD P Berry
Oct 23, 2008·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Takashi Tsuruo, Naoya Fujita
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Mar 26, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Donald C McMillan
Sep 23, 2009·Cell Cycle·Yadi Wu, Binhua P Zhou
Apr 10, 2010·Scandinavian Journal of Gastroenterology·Panagiotis HerasKonstantinos Kritikos
Nov 3, 2010·Journal of Thrombosis and Haemostasis : JTH·N M Bambace, C E Holmes
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernhard MlecnikJérôme Galon
Jun 11, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kei SuzukiPrasad S Adusumilli
Jul 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael J ProctorDonald C McMillan
Jul 19, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Naohiro KobayashiYukio Sato
Jun 27, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R CarruthersA C McDonald
Oct 25, 2012·Journal of Gynecologic Oncology·Supachai RaungkaewmaneeThaovalai Thavaramara
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Mehmet CelikbilekMehmet Yücesoy
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yasemin KemalMeltem Ozdemir
May 17, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Y KemalI Yücel

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Citations

Nov 1, 2017·International Journal of Clinical Oncology·Hiroshi KobayashiSakae Tanaka
Jul 31, 2018·Journal of Gastrointestinal Cancer·Monika MagdyAhmed Gaballah
Apr 22, 2017·World Journal of Gastroenterology : WJG·Jeong Won LeeSang Mi Lee
Mar 4, 2020·BMC Cancer·Jin-Hyuk ChoiSeung Soo Sheen

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