Changes in Noninvasive Liver Fibrosis Indices and Spleen Size During Chemotherapy: Potential Markers for Oxaliplatin-Induced Sinusoidal Obstruction Syndrome

Medicine
Sehhoon ParkJin-Soo Kim

Abstract

Oxaliplatin-based regimens are standard treatments for the patients with colorectal cancer (CRC) and advanced gastric cancer (AGC). However, owing to hepatic sinusoidal obstruction syndrome (SOS), the use of oxaliplatin sometimes results in splenomegaly. The aim of the present study was to evaluate the correlation between chemotherapy-associated changes of noninvasive liver fibrosis indices and volumetric changes of the spleen.From February 2004 to April 2014, patients with CRC or AGC receiving oxaliplatin-based chemotherapy were studied. The possibility of SOS development was evaluated before and after the oxaliplatin exposure with splenic volume index (SVI). Four different noninvasive liver fibrosis indices were used for risk analysis, namely age-platelet index (API), AST-to-platelet ratio index (APRI), platelet-to-spleen ratio (PSR), and fibrosis-4 score (FIB-4).A total of 275 patients were eligible for evaluation: 200 patients had CRC and 75 patients had AGC. Using the cutoff of SVI increase ≥ 0.3, 113 patients (41.1%) were positive for splenomegaly. The changes of indices significantly correlated with SVI increase. Adjusted odds ratios for those indices were as follows: API = 1.16 (95% confidential interval [CI], 1.01-1.32...Continue Reading

References

Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A de GramontA Bonetti
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Dec 26, 2001·Bone Marrow Transplantation·R M Szydlo
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J Fontana, Anna S F Lok
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Rubbia-BrandtB Terris
Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
May 5, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G FolprechtC-H Köhne
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul CalèsFrançoise Lunel
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C Rockey, D Montgomery Bissell
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas AloiaRené Adam
Feb 6, 2007·World Journal of Gastroenterology : WJG·Giada SebastianiAlfredo Alberti
May 25, 2007·Cancer Chemotherapy and Pharmacology·Yeon Hee ParkYoon-Koo Kang
May 13, 2008·Gastroenterology·Diarmuid S Manning, Nezam H Afdhal
Aug 12, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tony TrangNed Snyder
Dec 5, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sylvie NaveauThierry Poynard
Apr 9, 2009·Journal of Surgical Oncology·Eduardo SchifferCatherine M Pastor
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzRobert R McWilliams
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J OvermanScott Kopetz
Nov 9, 2010·Clinics in Liver Disease·Laura Rubbia-Brandt
Jan 22, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stella M MartínezXavier Forns
Apr 5, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuji MorineTohru Utsunomiya
Jan 7, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K ImaiUNKNOWN Kyusyu Study Group of Clinical Cancer (KSCC) ancillary study
May 23, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyu-Won JungJin Soo Lee
Dec 17, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Beomseok SuhBeLong Cho
May 15, 2015·Seminars in Liver Disease·Keyur PatelLaurent Castera

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
K ImaiKyusyu Study Group of Clinical Cancer (KSCC) ancillary study
© 2022 Meta ULC. All rights reserved