Changes in nuclear morphology in the human endometrial glandular epithelium in women with unexplained infertility

Human Reproduction
P DockeryI D Cooke

Abstract

In the light and electron microscopical study reported here, we documented the structure of the nucleus, nucleolus and nuclear channel system (NCS) in the uterine glandular epithelium in both fertile and infertile women during the early luteal phase. Nuclear volume was found to be larger in the infertile group at day 5 after the luteinizing hormone surge (LH+5) compared to day-matched fertile subjects. A two-way analysis of variance performed on nucleolar volume data from fertile and infertile women biopsied on days LH+5, +5, and +6 revealed a significant effect of condition but no effect of day or interaction. Nucleolar volume decreased from day LH+2 to day LH+6 in the fertile group, the sharpest decrease occurring between day LH+3 and day LH+4. The largest mean volume of the NCS was found at day LH+5 in the fertile group and day LH+6 in the infertile group. The results suggest a delay in the development of this organelle in the infertile women. The present study has documented alterations in the nuclei of uterine glandular cells from infertile patients. In these infertile women, there is also a delayed elaboration of the secretory apparatus and this delay correlates well with the delayed/reduced expression of a luteal-specifi...Continue Reading

Citations

Jul 10, 2003·Fertility and Sterility·Rebecca L DubowyHarvey J Kliman
Dec 18, 2013·Progress in Biophysics and Molecular Biology·Jayasree Sengupta, Debabrata Ghosh
Apr 13, 2007·Molecular Biology of the Cell·Nupur KitturU Thomas Meier
May 29, 2008·Journal of Cell Science·Elisa GuffantiU Thomas Meier
Nov 10, 2012·Fertility and Sterility·Michael J SzmygaU Thomas Meier
Oct 24, 2001·Biology of Reproduction·C A GrayT E Spencer
May 23, 2001·Biology of Reproduction·C A GrayT E Spencer
Jan 25, 2014·Reproductive Sciences·Edward J NejatU Thomas Meier
Nov 24, 2019·International Journal of Molecular Sciences·Lior PytowskiDavid J Vaux
Feb 8, 2008·Reproduction, Fertility, and Development·Gracy X RosarioGeetanjali Sachdeva
Nov 1, 2016·Nucleus·Marek Mateusz Drozdz, David John Vaux
Jul 28, 2021·Ultrastructural Pathology·Özdem KaraoğlanÖzgül Tap

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