PMID: 11924677Apr 2, 2002Paper

Changes in organ perfusion and weight ratios in post-simulated microgravity recovery

Acta Astronautica
Daniel B DeeverM L Witten

Abstract

Head-down tilt models have been used as ground-based simulations of microgravity. Our previous animal research has demonstrated that there are significant changes in fluid distribution within 2 h after placement in a 45 degrees head-down tilt (45HDT) position and these changes in fluid distribution were still present after 14 days of 45HDT. Consequently, we investigated changes in fluid distribution during recovery from 16 days of 45HDT. Changes in radioactive tracer distribution and organ/body weight ratio were examined in rats randomly assigned to a 45HDT or prone control group. The 45HDT rats were suspended for 16 days and then allowed to recover at the prone position 0, 77, 101, or 125 h post-suspension. Animals were injected with technetium-labeled diethylenetriamine pentaacetate (99mTcDTPA, MW=492 amu, physical half-life of 6.02 h) and then killed 30 min post-injection. Lungs, heart, liver, spleen, kidneys, and brain were harvested, weighed, and measured for radioactive counts. Statistical analyses included two-way analysis of variance (ANOVA) that compared 45HDT versus controls at the four experimental time points. The organ weight divided by the body weight ratio for the brain, heart, kidneys and liver in the 45HDT rats...Continue Reading

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Jul 17, 2013·Aviation, Space, and Environmental Medicine·William E Thornton, Frederick Bonato

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Citations

Nov 11, 2003·Acta Astronautica·Christopher Ryan Pettis, Mark Lee Witten
Jun 29, 2018·The Journal of Experimental Biology·Alexander A Andreev-AndrievskiyOlga L Vinogradova
Jun 10, 2003·Journal of Applied Physiology·C A RiveraC W Smith

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