Changes in ovarian cancer survival during the 20 years before the era of targeted therapy

BMC Cancer
Jung-Yun LeeYoung Joo Won

Abstract

The survival of patients with ovarian cancer has improved because of surgery and chemotherapy. This study aimed to estimate the changes in survival rates among Korean women with ovarian cancer prior to the introduction of targeted therapy for ovarian cancer. Data were obtained from the Korea Central Cancer Registry regarding patients who were diagnosed with epithelial ovarian cancer between 1995 and 2014. The relative survival rates were calculated for 5-year periods using the Ederer II method. Cox proportional hazard models were created to assess the associations of demographic and clinicopathological factors with ovarian cancer survival. During the study period, 22,880 women were diagnosed with epithelial ovarian cancer. The 5-year relative survival rate improved from 57.2% during 1995-1999 to 63.8% during 2010-2014 (P < 0.001). Survival outcomes improved between 1995 and 1999 and 2010-2014 for the serous and endometrioid carcinoma subtypes (P < 0.001). However, no improvements were observed for the mucinous and clear cell carcinoma subtypes (P = 0.189 and P = 0.293, respectively). Multivariate analysis revealed that younger age, early stage, recent diagnosis, primary surgical treatment, and non-serous histological subtype we...Continue Reading

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Dec 20, 2018·Frontiers in Oncology·Juan ZhouWen-Wen Zhang
Sep 10, 2020·International Journal of Molecular Sciences·Chao Lien LiuTsui Lien Mao
Dec 9, 2020·Critical Reviews in Oncology/hematology·Zahra Sadat RazaviHamed Mirzaei
May 18, 2021·Frontiers in Oncology·Dong Wook ShinKyu-Won Jung

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