Changes in Pain Processing in the Spinal Cord and Brainstem after Spinal Cord Injury Characterized by Functional Magnetic Resonance Imaging

Journal of Neurotrauma
Patrick W StromanMichael G Fehlings

Abstract

Traumatic spinal cord injury (SCI) has a number of devastating consequences, including high prevalence of chronic pain and altered pain sensitivity. The causes of altered pain states vary depending on the injury and are difficult to diagnose and treat. A better understanding of pain mechanisms after SCI is expected to lead to better diagnostic capabilities and improved treatments. We therefore applied functional magnetic resonance imaging (fMRI) of the brainstem and spinal cord in a group of participants with previous traumatic SCI to characterize changes in pain processing as a result of their injuries. The same thermal stimulus was applied to the medial palm (C8 dermatome) as a series of repeated brief noxious thermal pulses in a group of 16 participants with a cervical (n = 14) and upper thoracic (n = 2) injuries. Functional MRI of the brainstem and spinal cord was used to determine the neuronal activity evoked by the noxious stimulation, and connectivity between regions was characterized with structural equation modeling (SEM). The results show that pain ratings, the location and magnitude of blood oxygenation-level dependent fMRI results, and connectivity assessed with SEM varied widely across participants. However, the re...Continue Reading

References

Nov 1, 1984·The British Journal of Mathematical and Statistical Psychology·J J McArdle, R P McDonald
Dec 24, 1998·Journal of Neurophysiology·C A PorroP Baraldi
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
May 30, 2002·Progress in Neurobiology·Mark J Millan
Oct 23, 2002·Brain : a Journal of Neurology·Armin CurtSpyros S Kollias
Jun 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert C CoghillYi-Fen Yen
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R Staud, M Domingo
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan C Hains, Stephen G Waxman
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lino BecerraDavid Borsook
Oct 21, 2006·Nature Reviews. Neuroscience·Herta FlorTroels Staehelin Jensen
Dec 13, 2006·Pain·Roland StaudDonald D Price
Feb 3, 2009·The Journal of Pain : Official Journal of the American Pain Society·Christopher S NielsenDonald D Price
Oct 8, 2009·Neurorehabilitation and Neural Repair·Michael T JurkiewiczMary C Verrier
Jun 22, 2010·IEEE Transactions on Medical Imaging·Andriy Myronenko, Xubo Song
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Supinder S BediEdgar T Walters
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke A HendersonPhilip J Siddall
Mar 10, 2011·Current Pain and Headache Reports·Young Seob Gwak, Claire E Hulsebosch
May 19, 2011·Brain : a Journal of Neurology·Patrick FreundAlan J Thompson
Apr 7, 2012·The Journal of Pain : Official Journal of the American Pain Society·Jason G CraggsDonald D Price
Jul 25, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Karen D Davis, Massieh Moayedi
Jan 3, 2013·Advances in Experimental Medicine and Biology·Radi Masri, Asaf Keller
May 21, 2013·NeuroImage·P W StromanI Tracey
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Aaron KucyiKaren D Davis
Nov 26, 2013·The Journal of Pain : Official Journal of the American Pain Society·Nanna Brix FinnerupLars Werhagen
May 9, 2014·Journal of Magnetic Resonance Imaging : JMRI·Rachael L Bosma, Patrick W Stroman
Jun 18, 2014·NeuroImage. Clinical·Tom B MoleTuro J Nurmikko
Jul 30, 2014·Physical Medicine and Rehabilitation Clinics of North America·Elizabeth Roy Felix
Aug 1, 2014·The Journal of Pain : Official Journal of the American Pain Society·Christine E DobekPatrick W Stroman
Aug 22, 2014·Lancet Neurology·Troels S Jensen, Nanna B Finnerup
Dec 6, 2014·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Dwight MoulinUNKNOWN Canadian Pain Society
Sep 15, 2015·Human Brain Mapping·Rachael L BosmaPatrick W Stroman

❮ Previous
Next ❯

Citations

Dec 3, 2016·PloS One·Patrick W StromanRoland Staud
Jan 12, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shreyas Harita, Patrick W Stroman
Sep 28, 2017·Neural Plasticity·Young S GwakJoong Woo Leem
Sep 1, 2016·Journal of Experimental Neuroscience·Jamie L ReedJon H Kaas
May 13, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Thierry PaquetteMathieu PichÉ
Sep 12, 2018·Brain Sciences·Jocelyn M PowersPatrick W Stroman
Jun 28, 2019·Frontiers in Cellular Neuroscience·Hiroyuki KatohMichael G Fehlings
Sep 25, 2017·European Journal of Pain : EJP·T A McIverP W Stroman
Aug 1, 2020·Frontiers in Physiology·Sílvia S ChambelCélia D Cruz
Dec 20, 2017·Current Physical Medicine and Rehabilitation Reports·Ann S Choe
Mar 30, 2016·Pain·Kirsty Bannister, Anthony H Dickenson
Feb 5, 2021·ACS Chemical Neuroscience·Shin Jie Yong
Feb 23, 2021·Cephalalgia : an International Journal of Headache·Caroline M KopruszinskiFrank Porreca
May 1, 2021·International Journal of Molecular Sciences·Hye-Lan LeeKeung-Nyun Kim
Jul 17, 2021·NeuroImage·Anirban SenguptaJohn C Gore

❮ Previous
Next ❯

Software Mentioned

Medical Image Registration Toolbox
MatLab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.