Changes in Parkinson's disease sleep symptoms and daytime somnolence after bilateral subthalamic deep brain stimulation in Parkinson's disease

NPJ Parkinson's Disease
Siddharth KharkarKeyoumars Ashkan

Abstract

Deep brain stimulation (DBS) markedly improves motor function in advanced Parkinson's disease (PD), but its effect on sleep is less clear. Forty PD patients who had subthalamic DBS (STN-DBS) were identified from an on-going non-motor naturalistic longitudinal study (NILS). All patients were followed up for at least 6 months, 26 patients had a 1 year follow-up. A total PDSS score of 100 or less, a score in any PDSS-item of 6 or less, and a Epworth score of 10 or more were classified as being significant. Forty-five percent of patients reported significant improvement in the total PDSS score at 6 months, and 35% at 12 months. In terms of magnitude, the total PDSS score at 6 months was significantly improved from baseline while the improvement at 12 months was not statistically significant. The most frequently reported improvements were overall sleep quality and maintenance of sleep. Some patients reported worsening of the total PDSS score. More than half of the patients reporting daytime sleepiness at baseline had persistent sleepiness at 6 and 12 months. The mean Epworth Score did not improve because a significant number of patients without sleepiness at baseline reported new-onset sleepiness at 6 and 12 months. Neither medicati...Continue Reading

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Citations

Jan 8, 2020·Nature Reviews. Neuroscience·Malin ParmarClaire Henchcliffe
Dec 13, 2019·Frontiers in Pharmacology·Daniel de Castro MedeirosGilberto Fisone
Oct 22, 2020·NPJ Parkinson's Disease·Silje BjerknesMathias Toft
Oct 20, 2020·Journal of Parkinson's Disease·Stefanie T JostUNKNOWN EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group

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