Changes in PDGF concentration in surgically treated colorectal carcinoma

Advances in Medical Sciences
Maria ManturJ Wojszel

Abstract

The aim of the present study was to asses the effect of tumor advancement, differentiation grade and surgery treatment on PDGF- AB level and platelet (PLT) count depending on the site of blood collection. The study included 38 patients submitted to surgical treatment due to diagnosis of colorectal cancer (CRC) without remote metastasis: G2- 20 patients and group G3- 18 patients. The control group consisted of 24 healthy subjects. In CRC patients the blood samples was collected three times: 1) before surgery, 2) intrasurgically and 3) 90 days after surgery. Serum PDGF- AB concentration was determined by ELISA- Kit reagents. PDGF concentration in all the patients was several times higher than in the control group, irrespective of tumor differentiation grade and the site of blood collection. However the level of PDGF- AB in intraoperatively collected arterial blood and venous blood in group G3 (arterial blood- 379.9+/-12.1 ng/ml; venous blood- 398.4+/-13.2 ng/ml) was significantly higher than in group G2 (arterial blood- 169.4+/-88.6 ng/ml; venous blood- 194.2+/-84.0 ng/ml). No significant differences were observed between venous and arterial blood. No correlation was found between the PLT count and PDGF- AB concentration. High bl...Continue Reading

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Citations

Jan 1, 2009·Folia Histochemica Et Cytobiologica·M ManturD Lemancewicz
Apr 19, 2012·Journal of Tissue Engineering·Luis A SolchagaLeo B Snel
Jul 2, 2017·Cancer Metastasis Reviews·Preeti Kanikarla-MarieScott Kopetz
May 8, 2018·Frontiers in Oncology·Preeti Kanikarla-MarieDavid G Menter

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