Changes in pelvic organ prolapse mesh mechanical properties following implantation in rats

American Journal of Obstetrics and Gynecology
Daniela UlrichVincent Letouzey

Abstract

Pelvic organ prolapse (POP) is a multifactorial disease that manifests as the herniation of the pelvic organs into the vagina. Surgical methods for prolapse repair involve the use of a synthetic polypropylene mesh. The use of this mesh has led to significantly higher anatomical success rates compared with native tissue repairs, and therefore, despite recent warnings by the Food and Drug Administration regarding the use of vaginal mesh, the number of POP mesh surgeries has increased over the last few years. However, mesh implantation is associated with higher postsurgery complications, including pain and erosion, with higher consecutive rates of reoperation when placed vaginally. Little is known on how the mechanical properties of the implanted mesh itself change in vivo. It is assumed that the mechanical properties of these meshes remain unchanged, with any differences in mechanical properties of the formed mesh-tissue complex attributed to the attached tissue alone. It is likely that any changes in mesh mechanical properties that do occur in vivo will have an impact on the biomechanical properties of the formed mesh-tissue complex. The objective of the study was to assess changes in the multiaxial mechanical properties of synt...Continue Reading

References

Jul 1, 1996·American Journal of Obstetrics and Gynecology·R C BumpA R Smith
Feb 8, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·C R CostelloS A Grant
Oct 11, 2008·American Journal of Obstetrics and Gynecology·Rebecca U MarguliesJohn O L Delancey
Oct 11, 2008·American Journal of Obstetrics and Gynecology·Beri RidgewayJ Eric Jelovsek
Jan 7, 2010·International Urogynecology Journal·Arnaud ClavéHenri Clavé
May 25, 2010·American Journal of Obstetrics and Gynecology·Kari NieminenPentti K Heinonen
Apr 23, 2011·International Urogynecology Journal·Renaud de Tayrac, Vincent Letouzey
May 13, 2011·The New England Journal of Medicine·Daniel AltmanUNKNOWN Nordic Transvaginal Mesh Group
Dec 18, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·J Deprest, A Feola
Dec 18, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·A FeolaP Moalli
Dec 18, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·R LiangP A Moalli
Dec 18, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·S ManodoroJ Deprest
Dec 3, 2014·American Journal of Obstetrics and Gynecology·Aqsa A KhanJennifer T Anger
Dec 3, 2014·American Journal of Obstetrics and Gynecology·Andrew FeolaJan Deprest

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Citations

Jun 2, 2016·World Journal of Stem Cells·Stuart J Emmerson, Caroline E Gargett
Jun 21, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Elena MancusoPeter Culmer
Dec 31, 2016·International Urogynecology Journal·Sunil BalgobinClifford Y Wai
Jan 27, 2019·Female Pelvic Medicine & Reconstructive Surgery·Amy L AskewMegan S Bradley
Jun 25, 2019·F1000Research·Emma MironskaSheila MacNeil
Jun 1, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Annie MorchMichel Cosson
Aug 19, 2021·Archives of Gynecology and Obstetrics·Hui LiZhiyuan Dai

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