PMID: 7334004Dec 1, 1981Paper

Changes in peroxisomal fatty acid oxidation in the diabetic rat liver

Journal of Biochemistry
S HorieT Suga

Abstract

Changes in fatty acid oxidation of peroxisomes in the liver of alloxan-diabetic rats were studied. After injection of alloxan (150 mg/kg, subcutaneously), the activity of peroxisomal cyanide-insensitive beta-oxidation increased more rapidly than that of carnitine palmitoyltransferase, which was the rate-limiting step of mitochondrial beta-oxidation, and reached 3 times the control level at 7 days after the treatment. The peroxisomal beta-oxidation activity was more potent toward medium chain acyl-CoAs (C=10 and 12), though it was extremely low for shorter chain lengths. The activity of carnitine acetyltransferase increased to 2.4 times the control level and the change appeared mainly in the peroxisomal fraction. On the other hand, the activity of palmitoyltransferase increased to twice the control level, distributed mostly in the mitochondrial fraction. The activity of carnitine acyltransferase increased mainly in the peroxisomal fraction, and was higher for shorter and medium chain acyl-CoAs. These results suggest that peroxisomal fatty acid oxidation and transport of acetyl-CoA and medium chain acyl-CoA as well as NADH product in peroxisomes may be rapidly enhanced in response to the demand of organs for the urgent supply of ...Continue Reading

Citations

Oct 1, 1984·Archives of Toxicology·A M MitchellC R Elcombe
Dec 27, 1996·Annals of the New York Academy of Sciences·M BronfmanP Hidalgo
Jul 19, 2005·Plant Foods for Human Nutrition·Nandita SinghP S Rajini
Dec 8, 2006·Annals of the New York Academy of Sciences·Amr AminErnest Adeghate
Aug 4, 2018·Canadian Journal of Physiology and Pharmacology·Missaoui SamiraOlfa Tebourbi
Apr 21, 2019·FEBS Letters·Evan W KerrRoberta Leonardi
Oct 18, 1995·Molecular and Cellular Biochemistry·R KakkarK Prasad
Nov 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W W Just, F U Hartl
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T Locci-Cubeddu, E Bergamini
Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S Yokota, K Asayama
Nov 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T IkedaT Suga
Jul 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Robert C NolandRonald N Cortright
Jun 1, 2000·Clinical and Experimental Pharmacology & Physiology·X F Zhang, B K Tan
Sep 4, 2020·The Journal of Toxicological Sciences·Akio KobayashiShoichiro Sugai
Sep 27, 2012·Molecular Systems Biology·Rui Wang-SattlerThomas Illig
May 10, 2018·Frontiers in Endocrinology·Suniti VaishyaVasudevan Seshadri
Mar 9, 2019·Journal of Lipid Research·Stephanie A ShumarRoberta Leonardi
May 22, 2016·Diabetes Care·Marta Guasch-FerréFrank B Hu
Sep 30, 1999·Environmental Health Perspectives·J Youssef, M Badr
Feb 26, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·R Scott RectorJamal A Ibdah
May 1, 2019·Journal of Lipid Research·Stephanie A ShumarRoberta Leonardi
Apr 3, 2020·Progress in Lipid Research·Philippe NaquetRoberta Leonardi
Mar 22, 2000·Mutation Research·A I ChoudhuryD R Bell
Mar 1, 1997·General Pharmacology·M OrellanaE Del Villar
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·B DesvergneW Wahli
Jun 1, 1983·Biochemical Pharmacology·T Locci-Cubeddu, E Bergamini
Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P BentleyH J Wiegand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.