PMID: 6688364Aug 29, 1983Paper

Changes in phospholipid composition of lung surfactant during development in the fetal lamb

Biochimica Et Biophysica Acta
B J BensonW H Tooley


The lung surfactant isolated from pulmonary fluid of fetal sheep changes both in amount and composition during gestation. Total phosphatidylcholine (PC) and its most surface-active components, disaturated PC, are present at very low levels 3-4 weeks prior to term and rise to adult levels 3-4 days before birth. The acidic phospholipids appear with a different time course. Phosphatidylserine reaches elevated levels about 21 days before birth. Phosphatidylinositol begins to increase at about 130 days of gestation. Phosphatidylglycerol is not a component (less than 1%) of the surfactant in this fetal lung fluid. At term, phosphatidylinositol is the major acidic phospholipid found in these fluids.


Dec 1, 1975·Journal of Applied Physiology·E J MescherW H Tooley
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Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J Benson
Jan 1, 1963·Biologia Neonatorum. Neo-natal Studies·F H ADAMSL FAGAN

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