Changes in physicians' practice of prescribing cyclooxygenase-2 inhibitor after market withdrawal of rofecoxib: a retrospective study of physician-patient pairs in Taiwan

Clinical Therapeutics
Fei-Yuan HsiaoWeng-Foung Huang

Abstract

Safety concerns regarding severe cardiovascular events associated with the use of selective cyclooxygenase-2 (COX-2) inhibitors resulted in the market withdrawal of rofecoxib in September 2004. Using Taiwan's National Health Insurance 2003-;2004 claims database, this population-based retrospective cohort study assessed changes in physicians' practice of prescribing a COX-2 inhibitor after market withdrawal of rofecoxib. Patients with rheumatoid arthritis (RA) or osteoarthritis (OA) who were chronic users of COX-2 inhibitors before market withdrawal of rofecoxib were identified. Eligible chronic users of COX-2 inhibitors were patients who received >or=3 consecutive prescriptions for celecoxib or rofecoxib to treat RA or OA between April 1 and September 30, 2004. The main outcome evaluated in this study was the volume of celecoxib prescribing for each patient by his or her prescribing physician at the first postwithdrawal outpatient visit related to RA or OA. For each matched physician, we calculated the prescribing practice indexes before and after the withdrawal of rofecoxib to assess changes in prescribing practice. A higher value of the index represented less potential that patients with a history of cardiovascular events who...Continue Reading

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Citations

Aug 2, 2012·Therapeutic Advances in Musculoskeletal Disease·Nahid Akhtar, Tariq M Haqqi
Nov 16, 2014·BMC Complementary and Alternative Medicine·Ding-Qian WuLi Ba
Apr 6, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Chin-wern Chan, Philip Peng
Oct 9, 2015·BMC Medicine·Daniel J NivenHenry Thomas Stelfox
Sep 16, 2014·ACS Medicinal Chemistry Letters·Mohamed F RadwanTamer S Kaoud
Sep 4, 2017·European Journal of Clinical Pharmacology·Antoine ParienteBernard Bégaud
Jun 30, 2011·Immunopharmacology and Immunotoxicology·Jong-Hyun HanSung-Hoon Kim
Feb 2, 2013·Chemical & Pharmaceutical Bulletin·Khaled Abouzid Mohamed AbouzidSawsan Abo-Bakr Zaitone
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