PMID: 19120020Jan 6, 2009Paper

Changes in physicochemical parameters and alpha-crystallin expression in the lens during cataract development in OXYS rats. 5

Biochemistry. Biokhimii︠a︡
Yu V RumyantsevaN G Kolosova

Abstract

The pathogenesis of cataract is associated with oxidative stress and with altered crystallin expression but it is still understood incompletely. In this study, the senescence-accelerated OXYS rats were used as a model. The first biomicroscopic signs of cataract in OXYS rats were registered at the age of 1.5 months; at 3 months morbidity reached 90%, and at 6 months it reached 100%. Cataract manifestation progresses: at 24 months mature cataract was detected in 90% of eyes of OXYS rats, whereas in 80% of Wistar rat eyes only initial signs of this disease were detected. Analysis of lens redox-parameters has shown that in OXYS rats the intensity of tryptophan fluorescence is higher, the GSH content being higher at 2 months but during formation of mature cataract at 13, 18, and 24 months being lower than in Wistar rats. Decrease in solubility of OXYS rat lens proteins was observed at the age of 13 months. At the age of 3 months gene expression of alphaA-crystallin and alphaB-crystallin was 3-fold and 25% lower, respectively, than in Wistar rats. At the age of 14 months there was a 27-fold decrease in expression of alphaB-crystallin in OXYS rats and it became 21-fold lower than in control. Proteins are synthesized in lens epithelial...Continue Reading

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Citations

Apr 7, 2010·Biochemistry. Biokhimii︠a︡·V B SaprunovaL E Bakeeva
Jun 25, 2013·Experimental Eye Research·Egor A DobretsovYuri P Tsentalovich
Feb 14, 2013·Biochimica Et Biophysica Acta·Evgeniya A SattarovaGeorgy A Nevinsky
Jun 10, 2014·Experimental Eye Research·Vadim V YansholeYuri P Tsentalovich
May 16, 2017·Experimental Gerontology·Natalia A MuralevaNataliya G Kolosova
Oct 1, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yuliya V RumyantsevaNataliya G Kolosova
Jun 15, 2015·Biochemistry. Biokhimii︠a︡·Ch M El'darovL E Bakeeva
Sep 6, 2013·Advances in Gerontology = Uspekhi Gerontologii·N A StefanovaN G Kolosova
Oct 1, 2011·Advances in Gerontology = Uspekhi Gerontologii·V I RykovaN G Kolosova
May 10, 2013·Cell Cycle·Oyuna S KozhevnikovaNatalia G Kolosova

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