Changes in placental progesterone receptors in term and preterm labour

Placenta
E ZachariadesE Karteris

Abstract

Currently, preterm labour is associated with increased fetal mortality and morbidity and is often associated with elevated levels of inflammatory cytokines. However, the exact mechanisms that lead to this pathology are not fully elucidated. In the present study evidence was obtained using a specific membrane progesterone receptor (mPR) agonist, Org OD 02-0, that the progestin antagonism of apoptotic effects of a cytokine, IL-1β, on human placental BeWo cells is mediated through mPRs. Therefore the aim of this study was to determine whether the gene expression of mPRs and all other known progesterone receptors changes in human placentas at term and during labour. Quantitative PCR (qPCR) in clinical samples revealed a 2.8 fold decrease of mPRβ in labouring comparing to non-labouring tissues and 4.6 fold higher levels of mPRγ in preterm mPRγ compared to term placentas. The ratio of mPRα to PR-B was increased in term compared to preterm samples, whereas it was decreased in labour compared to non-labour placentas. There was also a high correlation between mPRα and PGRMC1 expression irrespective of pathologies. Collectively, our data indicates that changes in the ratios of progesterone receptors rather than individual fluctuations mi...Continue Reading

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Citations

Oct 31, 2015·Journal of Reproductive Immunology·Ana AreiaAnabela Mota-Pinto
Feb 3, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·A AreiaA Mota-Pinto
Sep 10, 2015·Journal of Perinatal Medicine·Ana Luísa AreiaAnabela Mota-Pinto
Feb 16, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Michael C Byrns
Jun 10, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tingting FengKok H Tan
Dec 19, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·David K StevensonPaul H Wise
Nov 10, 2016·Fetal and Pediatric Pathology·Ana Luísa AreiaLina Carvalho
Apr 20, 2021·Frontiers in Veterinary Science·Ahmed M NagyWalter H Hsu
Oct 9, 2021·Nature Ecology & Evolution·Hans RecknagelKathryn R Elmer

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