Abstract
Currently, preterm labour is associated with increased fetal mortality and morbidity and is often associated with elevated levels of inflammatory cytokines. However, the exact mechanisms that lead to this pathology are not fully elucidated. In the present study evidence was obtained using a specific membrane progesterone receptor (mPR) agonist, Org OD 02-0, that the progestin antagonism of apoptotic effects of a cytokine, IL-1β, on human placental BeWo cells is mediated through mPRs. Therefore the aim of this study was to determine whether the gene expression of mPRs and all other known progesterone receptors changes in human placentas at term and during labour. Quantitative PCR (qPCR) in clinical samples revealed a 2.8 fold decrease of mPRβ in labouring comparing to non-labouring tissues and 4.6 fold higher levels of mPRγ in preterm mPRγ compared to term placentas. The ratio of mPRα to PR-B was increased in term compared to preterm samples, whereas it was decreased in labour compared to non-labour placentas. There was also a high correlation between mPRα and PGRMC1 expression irrespective of pathologies. Collectively, our data indicates that changes in the ratios of progesterone receptors rather than individual fluctuations mi...Continue Reading
References
Nov 1, 1984·American Journal of Obstetrics and Gynecology·F S Khan-Dawood, M Y Dawood
Dec 4, 1996·Biochemical and Biophysical Research Communications·E FalkensteinM Wehling
May 23, 2002·Recent Progress in Hormone Research·Orla M ConneelyBert W O'Malley
Oct 28, 2004·Thrombosis Research·Neil M GudeRoger G King
Apr 13, 2005·Placenta·Robert C Tuckey
Oct 11, 2005·The Journal of Endocrinology·M S FernandesJ J Brosens
Feb 17, 2006·Molecular Human Reproduction·Neil R ChapmanStephen C Robson
Feb 18, 2006·Molecular Endocrinology·Emmanouil KarterisPeter Thomas
Mar 4, 2006·Endocrinology·J J PelusoMartin Wehling
May 2, 2006·American Journal of Obstetrics and Gynecology·Roberta MackenzieMary E Hannah
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Amy A MerlinoSam Mesiano
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Mark TattersallMark R Johnson
Apr 29, 2008·Molecular and Cellular Endocrinology·Ling ZhangJames K Pru
Jul 8, 2008·Steroids·Jessica L SmithThomas J Lyons
Oct 23, 2008·Nucleic Acids Research·Lars J JensenChristian von Mering
Feb 24, 2009·Clinical Chemistry·Harris P Y FanNelson L S Tang
Jan 26, 2010·Journal of Reproductive Immunology·Aurelija DubickeGunvor Ekman-Ordeberg
Jan 26, 2010·Steroids·Jan KelderPeter Thomas
Dec 7, 2010·Molecular Human Reproduction·Wen WuRobert E Garfield
Jan 11, 2011·American Journal of Reproductive Immunology : AJRI·Camila MarconiMárcia Guimarães da Silva
Apr 2, 2011·International Journal of Molecular Medicine·Elena ZachariadesEmmanouil Karteris
Citations
Oct 31, 2015·Journal of Reproductive Immunology·Ana AreiaAnabela Mota-Pinto
Feb 3, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·A AreiaA Mota-Pinto
Sep 10, 2015·Journal of Perinatal Medicine·Ana Luísa AreiaAnabela Mota-Pinto
Feb 16, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Michael C Byrns
Jun 10, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tingting FengKok H Tan
Dec 19, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·David K StevensonPaul H Wise
May 23, 2018·Reproductive Sciences·Liping FengAmy P Murtha
Nov 10, 2016·Fetal and Pediatric Pathology·Ana Luísa AreiaLina Carvalho
Mar 15, 2020·Theriogenology·Thanya BunmaAnna T Grazul-Bilska
Sep 21, 2019·Molecular and Cellular Endocrinology·C FraichardJ Guibourdenche
Apr 20, 2021·Frontiers in Veterinary Science·Ahmed M NagyWalter H Hsu
Apr 21, 2021·Seminars in Perinatology·David K StevensonRonald J Wong
May 8, 2021·BMC Immunology·João MendesAnabela Mota-Pinto
Oct 9, 2021·Nature Ecology & Evolution·Hans RecknagelKathryn R Elmer