PMID: 3767294Sep 1, 1986Paper

Changes in plasma and buffy layer vitamin C concentrations following major surgery: what do they reflect?

Annals of Clinical Biochemistry
C J SchorahR F King

Abstract

Plasma and buffy layer vitamin C concentrations have been measured in 19 patients before and following major surgery, and falls of 36% and 43% respectively were recorded on the first post-operative day. However, the change in the buffy layer could not be accounted for by a change in the concentration of vitamin C in platelets, mononuclear cells or polymorphonuclear leucocytes, the cell types which form the buffy layer. The buffy layer change could be explained by a post-surgical increase in the number of polymorphonuclear leucocytes which, when the buffy layer vitamin C is expressed per 10(8) white cells, dilutes the platelet and mononuclear cell contribution to the buffy layer vitamin C concentration. The fall in buffy layer vitamin C does not, therefore, reflect any increased demand for white cell vitamin C in the immediate post-operative period, although the decrease in plasma vitamin C could imply some increased utilisation or redistribution of the non-cellular compartment.

References

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Citations

Nov 9, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·A PeretzJ P Famaey
Aug 9, 2005·The Journal of Surgical Research·A RümelinU Fauth
Nov 9, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·F Gidden, A Shenkin
Jul 10, 2003·Journal of Toxicology and Environmental Health. Part a·Rafael MateoAntonio Ramis
Aug 16, 2003·The Veterinary Record·J PérezC Tarradas
Aug 1, 1992·The Proceedings of the Nutrition Society·C J Schorah

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