Abstract
Plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels increase after cardiopulmonary bypass (CPB) in pediatric patients. However, the exact reason for the postoperative increase remains unclear. This study elucidated the perioperative changes in plasma natriuretic peptide levels in children undergoing surgical isolated atrial septal defect (ASD) closure. Between 2010 and 2012, 24 pediatric patients (median 7.1, range 2.7-15.7 years) underwent surgery for simple ASD using CPB under ventricular fibrillation (Group A, 16 patients) or under cardiac arrest (Group B, 8 patients). Natriuretic peptide levels were measured before surgery, on postoperative day 0, 1, 3, and at the first outpatient visit. The pulmonary to systemic blood flow ratio (Qp/Qs) was estimated by echocardiography using an index of right ventricle end-diastolic area. Preoperative natriuretic peptide levels positively correlated with the Qp/Qs. Plasma ANP levels peaked on postoperative day 0, and its values were higher in Group A than in Group B patients (p < 0.001). Plasma BNP levels increased significantly in both Groups on postoperative day 1, and its values were significantly greater in Group A than in Group B patients (p = 0.007). T...Continue Reading
References
Sep 1, 1992·British Heart Journal·M BurchA Ationu
Aug 1, 1993·Cardiovascular Research·A AtionuN D Carter
Apr 16, 1998·American Heart Journal·S GlobitsR Pacher
Sep 26, 2000·The Journal of Thoracic and Cardiovascular Surgery·N YoshimuraC Shimazu
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Yoshio OotakiTomomi Hasegawa
Mar 31, 2004·The American Journal of Cardiology·Giuseppe SantoroRaffaele Calabrò
Oct 16, 2004·Chest·Lok Bin YapJohn Gerard Coghlan
Sep 13, 2005·The Journal of Thoracic and Cardiovascular Surgery·John M CostelloDenise M Goodman
Mar 7, 2006·The Journal of Thoracic and Cardiovascular Surgery·Chie-Youn ShihJeffrey R Fineman
Jun 7, 2006·International Journal of Cardiology·Andreas KochHelmut Singer
Mar 29, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·En-Ting WuShunji Sano
May 29, 2007·Pediatric Cardiology·H OzhanM Yazici
Oct 2, 2007·The Journal of Thoracic and Cardiovascular Surgery·Jong-Hau HsuJeffrey R Fineman
Nov 27, 2007·The Annals of Thoracic Surgery·Richard D MainwaringHessam Fallah
Jan 9, 2008·The Journal of Thoracic and Cardiovascular Surgery·Rowan WalshKaie Ojamaa
Apr 1, 2008·The Journal of Thoracic and Cardiovascular Surgery·Jong-Hau HsuJeffrey R Fineman
Dec 8, 2009·The American Journal of Cardiology·Satoshi MasutaniHideaki Senzaki
Jun 26, 2010·Congenital Heart Disease·Matthew F NiednerAlexander Rodarte
Oct 12, 2010·Pediatric Cardiology·Bibhuti B Das
Jan 8, 2011·Echocardiography·Omer UzBekir Sitki Cebeci
Jan 30, 2014·Heart Failure Reviews·Massimiliano CantinottiAldo Clerico