PMID: 8938548Nov 1, 1996Paper

Changes in plasma endothelin-1 and Big endothelin-1 induced by transjugular intrahepatic portosystemic shunts in patients with cirrhosis and refractory ascites

Journal of Hepatology
J P MartinetG Pomier-Layrargues

Abstract

Endothelin-1 (ET-1) is a potent vasoconstrictor that may be involved in the pathogenesis of splanchnic and renal hemodynamic changes associated with portal hypertension. The aim of this study was to measure the concentration of ET-1 and of its precursor Big endothelin-1 (Big ET-1) in the systemic circulation as well as in the splanchnic and renal venous beds and to evaluate changes after the relief of portal hypertension following transjugular intrahepatic portosystemic shunt placement. Plasma concentrations of ET-1 and of Big ET-1 were measured in the vena cava, renal vein, hepatic vein and portal vein in ten patients with cirrhosis and refractory ascites before and 1-2 months after transjugular intrahepatic portosystemic shunt. The porto-caval gradient, creatinine clearance, plasma aldosterone and renin activity, as well as daily urinary sodium excretion were measured at the same time. The plasma concentration of ET-1 and Big ET-1, respectively, in peripheral blood of normal volunteers were 0.28 +/- 03 and 3.95 +/- 0.34 pg/ml; the concentrations of both peptides were higher in patients with cirrhosis, both in vena cava (0.61 +/- 0.14 and 10.01 +/- 1.47 pg/ml), hepatic vein (0.62 +/- 0.13 and 13.93 +/- 1.77 pg/ml), portal vein...Continue Reading

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Citations

Feb 12, 1998·Journal of Hepatology·J SalóJ Rodés
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N NagasueT Harada
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Dharmesh KapoorRajiv Jalan
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ahmed Helmy, Peter C Hayes
Jan 14, 2005·Gut·E Redondo-CerezoJ A González-Martín
Nov 26, 2013·Clinics in Chest Medicine·Nadine Al-Naamani, Kari E Roberts
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·P DeltenreD Lebrec
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Mar 21, 2018·Current Pain and Headache Reports·Afrim IljaziAnders Hougaard
Nov 15, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yukihiro YokoyamaJian X Zhang

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