PMID: 9182470Jun 15, 1997Paper

Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure. VA Cooperative Study Group on AIDS

Annals of Internal Medicine
W A O'BrienJ D Hamilton

Abstract

Markers are needed for assessing response to antiretroviral therapy over time. The CD4+ lymphocyte count is one such surrogate, but it is relatively weak. To assess the association of changes in plasma human immunodeficiency virus (HIV) RNA level and CD4+ lymphocyte count with progression to the acquired immunodeficiency syndrome (AIDS). Analysis of data from a subset of patients in a multicenter, randomized, clinical trial. Six Veterans Affairs medical centers and one U.S. Army medical center. 270 symptomatic HIV-infected patients from the Veterans Affairs Cooperative Study on AIDS. Patients were randomly assigned to receive zidovudine or placebo initially; a cross-over protocol was established for patients receiving placebo who had disease progression. Reverse transcriptase polymerase chain reaction on cryopreserved plasma samples, previously obtained CD4+ lymphocyte counts, and clinical events. For each decrease of 0.5 log10 copies/mL in plasma HIV RNA level, averaged over the 6 months after randomization, the relative risk (RR) for progression to AIDS was 0.67 (P < 0.001). In a subset of 70 treated patients with long-term follow-up, a return to baseline plasma HIV RNA levels within 6 months of randomization was associated w...Continue Reading

Citations

Feb 18, 1999·Journal of Medical Virology·E Puchhammer-StöcklF X Heinz
Jul 18, 2000·Journal of Medical Virology·D MuirD Pillay
Jul 13, 2006·Archives of Pharmacal Research·Rafik SamuelByungse Suh
Nov 4, 2000·Archives of Pharmacal Research·R Samuel, B Suh
Oct 13, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Prabha S ChandraMahendra Kumar
Apr 24, 2010·Medical & Biological Engineering & Computing·Ali Asgar S BhagatChwee Teck Lim
Nov 30, 2000·Current Infectious Disease Reports·M Holodniy
Apr 6, 2012·Immunologic Research·Benjamin K Chen
Nov 14, 1998·Disease-a-month : DM·H W HorowitzG P Wormser
Dec 7, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Annemarie BergerHolger F Rabenau
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·M V Ragni
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J C PalomaresA Alejo
Feb 11, 2005·The New England Journal of Medicine·Gillian D SandersDouglas K Owens
Jul 26, 2002·The New England Journal of Medicine·Scott D HalpernArthur L Caplan
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pedro CahnDouglas Mayers
Oct 29, 2000·AIDS Patient Care and STDs·M Núñez, V Soriano
Mar 10, 2004·AIDS Patient Care and STDs·James B Peter, J Sanders Sevall
Apr 20, 1999·AIDS·UNKNOWN Delta Coordinating Committee, UNKNOWN Delta Virology Committee
Dec 28, 2000·AIDS·B V RoussanovJ V Giorgi
May 10, 2001·Clinical Obstetrics and Gynecology·H Burger, B Weiser
Aug 15, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·Z LiuJ V Giorgi
Sep 10, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C VidalC Tortajada
Jun 4, 2008·The Pediatric Infectious Disease Journal·Elijah PaintsilWarren A Andiman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.