Changes in plasma PPARs levels in migraine patients

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Zhang He-minLiu Suli

Abstract

The aim of this study was to observe the change in plasma PPARs (peroxisome proliferator-activated receptors) level during various periods and in different subtypes in migraine patients. We divided 227 patients with migraine into 2 main groups: the attack period group (n=98) and the attack-free period group (n=129). Patients were further divided into 4 subgroups according to whether they had aura symptoms. The control group consisted of 100 healthy subjects. We collected the clinical data of patients and measured the plasma levels of PPARs using enzyme-linked immunoassay (ELISA). We used SPSS software for statistical analysis. We found no significant difference in age, BMI, blood pressure, or blood lipid level among migraine patients during the headache attack period and during the headache-free period compared with the control group. The PPARα and PPARβ/δ levels during the headache attack period were significantly higher than during the headache free period and in healthy controls. The PPARγ levels during the headache attack period were significantly lower than those during the headache-free period and in the healthy control group. The PPARs levels during the headache attack period were significantly different from those durin...Continue Reading

References

Jan 15, 2005·Progress in Neurobiology·M A Dahlem, E P Chronicle
Apr 7, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Gerhard KrönkeNorbert Leitinger
Nov 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·Nimesh S A PatelSalvatore Cuzzocrea
Jan 7, 2009·PPAR Research·Liliane Michalik, Walter Wahli
Oct 20, 2009·Neurobiology of Disease·Anna P AndreouPeter J Goadsby
Mar 31, 2010·Seminars in Neurology·F Michael Cutrer
May 29, 2010·Pharmacological Reports : PR·Leszek BoćkowskiKrzysztof Sendrowski
Sep 12, 2013·Neuroscience Letters·Levente SzalardyPeter Klivenyi
Mar 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jordan B JahrlingKelly T Dineley
Jan 27, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ying JiangChangqing Li

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Citations

Oct 29, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhang LigongDiao Xiaojun
Jan 4, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chao LiHemin Zhang

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Methods Mentioned

BETA
enzyme-linked immunoassay
MDA
pharmacotherapy

Software Mentioned

SPSS

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