Abstract
The aim of the study was to compare the changes in plasma renin activity induced by a vasodilator in normal dogs and in dogs with an impaired cardiac reserve. In normal conscious dogs, a 60-min nitroprusside infusion increased plasma renin activity from 1.05 +/- 0.26 to 8.35 +/- 1.20 ng, angiotensin I ml-1 h-1 (P less than 0.002) and heart rate from 83 +/- 6 to 149 +/- 15 beats/min (P less than 0.002). In five dogs in which a aortocaval fistula had been created 4 weeks earlier, the same infusion still increased plasma renin activity but significantly less than in normal dogs (0.90 +/- 0.29 to 4.44 +/- 0.64 ng ml-1 h-1; P less than 0.01) and the heart rate was unchanged (134 +/- 4 to 139 +/- 7 beats/min; NS). Similarly, in five dogs with a previous myocardial infarction, the heart rats response to nitroprusside was blunted (108 to 107 beats/min;NS) and plasma renin activity increased less than in normal dogs. Plasma renin activity also increased acutely after hydralazine administration in dogs which myocardial infarction (1.05 +/- 0.26 to 8.99 +/- 0.79 ng ml-1 h-1; P less than 0.05); after 1 week of hydralazine, plasma volume had increased from 54.9 +/- 0.9 ml kg-1 to 74.5 +/- 4.9 ml kg-1 (P less than 0.05) and plasma renin acti...Continue Reading
References
Jan 1, 1976·Progress in Cardiovascular Diseases·J Ross
Jun 1, 1976·The Journal of Clinical Investigation·L WatkinsA C Barger
Jul 1, 1979·Circulation Research·H PouleurJ Ross
Jan 1, 1978·Circulation·N A AwanD T Mason
Feb 1, 1978·Circulation Research·M D ThamesD E Donald
Jun 1, 1978·Circulation Research·C D FlombaumR S Gadhok
Nov 1, 1978·Circulation·C CurtissJ A Franciosa
Dec 1, 1976·Circulation·K ChatterjeeA Norman
Aug 1, 1977·The Journal of Clinical Investigation·I H ZuckerJ P Gilmore
Jul 1, 1977·The American Journal of Cardiology·I KhatriE D Freis
Aug 1, 1977·Journal of Clinical Pharmacology·M GutkinR S Modlinger
Feb 1, 1975·Circulation·R R MillerD T Mason
Mar 25, 1972·Lancet·J A FranciosaJ N Cohn
Apr 1, 1972·The Journal of Clinical Investigation·C B HigginsE Braunwald
Dec 1, 1974·Annals of Internal Medicine·J N CohnJ A Snow
Jul 1, 1973·Circulation Research·W A PettingerK Keeton
Jun 1, 1966·The Biochemical Journal·W S PeartN Stone
Feb 1, 1970·Circulation Research·T Sano, T Sawanobori
May 1, 1967·The Journal of Clinical Investigation·Y KanekoH Ueda
Dec 1, 1967·The American Journal of Physiology·J C HarlanT Q Richardson
Sep 1, 1981·Circulation·M PackerR Gorlin
Feb 1, 1980·Circulation·H PouleurJ Ross
Aug 1, 1953·Circulation·E D FREISE A PARTENOPE
Oct 1, 1955·British Heart Journal·J D AITCHISONE A PRIEST