Changes in platelet markers of obsessive-compulsive patients during a double-blind trial of fluvoxamine versus clomipramine

Pharmacopsychiatry
D MarazzitiG B Cassano

Abstract

Abnormalities of platelet serotonin (5-HT) transporter, which are supposed to reflect similar dysfunctions in the central nervous system (CNS), have been reported in obsessive-compulsive disorder (OCD). Other platelet parameters altered in OCD are represented by phenolsulfotransferase (PST) activity, an enzyme involved in the catabolism of catecholic neuro-transmitters, and peripheral benzodiazepine receptors. Since no information is available on the behavior of these putative markers during antiobsessive treatments, the aim of the present study was to measure and compare 3H-imipramine (3H-IMI) binding, which labels the 5-HT transporter, PST activity, and 3H-PK 11,195 binding, which labels peripheral benzodiazepine receptors, in a group of 18 patients with obsessive-compulsive disorder (OCD) before and after a treatment with fluvoxamine versus clomipramine. The results showed that at baseline the patients had a decreased number of 3H-IMI binding sites, which correlated negatively with the Y-BOCS total score, an increased PST activity and no difference in 3H-PK 11,195 binding, as compared with healthy volunteers. After eight weeks of treatment with either clomipramine or fluvoxamine, which was effective in all patients, the numb...Continue Reading

Citations

Aug 17, 2002·Psychoneuroendocrinology·Donatella MarazzitiGiovanni B Cassano
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard DelormeMarion Leboyer
Jan 8, 2004·Journal of Clinical Psychopharmacology·Richard DelormeMarion Leboyer
Apr 11, 2001·Journal of Clinical Child Psychology·M A Grados, M A Riddle
Feb 10, 2004·CNS Spectrums·John H GreistUNKNOWN World Council of Anxiety

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