Changes in pre-dialysis blood pressure variability in the first year of dialysis associate with mortality in European hemodialysis patients: a retrospective cohort study on behalf of the MONDO Initiative.

Journal of Human Hypertension
Marijke J E DekkerJochen G Raimann

Abstract

Pre-hemodialysis systolic blood pressure variability (pre-HD SBPV) has been associated with outcomes. The association of a change in pre-HD SBPV over time with outcomes, and predictors of this change, has not yet been studied. Therefore, we studied this in a cohort of 8825 incident hemodialysis (HD) patients from the European Monitoring Dialysis Outcomes Initiative database. Patient level pre-HD SBPV was calculated as the standard deviation of the residuals of a linear regression model of systolic blood pressure (SBP) over time divided by individual mean SBP in the respective time periods. The pre-HD SBPV difference between months 1-6 and 7-12 was used as an indicator of pre-HD SBPV change. The association between pre-HD SBPV change and all-cause mortality in year 2 was analyzed by multivariate Cox models. Predictors of pre-HD SBPV change was determined by logistic regression models. We found the highest pre-HD SBPV tertile, in the first 6 months after initiation of HD, had the highest mortality rates (adjusted HR 1.44 (95% confidence intervals (95% CI): 1.15-1.79)). An increase in pre-HD SBPV between months 1-6 and 7-12 was associated with an increased risk of mortality in year 2 (adjusted HR 1.29 (95% CI: 1.05-1.58)) compared...Continue Reading

References

Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stewart H LambieChristopher W McIntyre
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Brian D BradburyBrenda W Gillespie
Aug 30, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Steven M BrunelliHarold I Feldman
Apr 10, 2009·Clinical Journal of the American Society of Nephrology : CJASN·James O BurtonChristopher W McIntyre
Nov 3, 2010·Seminars in Dialysis·Christopher W McIntyre
Mar 16, 2012·Journal of Nephrology·Biagio Di IorioFrancesco Gaetano Casino
Sep 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Biagio Di IorioAntonio Bellasi
Jan 25, 2013·Blood Purification·Len A UsvyatPeter Kotanko
Mar 12, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jennifer E FlytheSteven M Brunelli
Mar 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Ciaran J McMullanJohn P Forman
Jun 6, 2013·Blood Purification·Francesca Mallamaci, Giovanni Tripepi
Jun 28, 2013·Journal of Human Hypertension·T I ChangG M Chertow
Feb 6, 2014·Blood Purification·Gero D von GersdorffPeter Kotanko
Jul 1, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji AokiTsutomu Imaizumi
Jan 31, 2015·Current Opinion in Nephrology and Hypertension·Jennifer E Flythe, Steven M Brunelli

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