Changes in prescribing for bipolar disorder between 2009 and 2016: national-level data linkage study in Scotland.

The British Journal of Psychiatry : the Journal of Mental Science
Laura M LyallDaniel J Smith

Abstract

People with bipolar disorder typically require long-term pharmacological treatment to prevent episodes of depression or mania. However, evidence-based guidelines are often not followed by prescribers and, in some countries, prescribing of lithium is in decline. Polypharmacy is also common in bipolar disorder.AimsTo employ a data linkage approach to describe and evaluate prescribing patterns in bipolar disorder in Scotland between 2009 and 2016. By linking prescribing data to the electronic Scottish Morbidity Records, we identified a cohort of 23 135 patients with bipolar disorder who were prescribed psychotropic medication between 2009 and 2016. We examined trends in proportions of patients prescribed each of six drug categories. Random effects logistic models examined change in prescribing over years of interest. The most common form of treatment was antidepressant monotherapy (24.96%), with only 5.90% of patients receiving lithium monotherapy. Prescribing of antipsychotics and anti-epileptics increased from 2009 to 2016 (antipsychotics: odds ratio 1.16, 95% CI 1.15-1.18; anti-epileptics: odds ratio 1.34, 95% CI 1.32-1.36), whereas prescribing of lithium decreased (odds ratio 0.83, 95% CI 0.82-0.85). Prescribing of valproate d...Continue Reading

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Citations

Sep 5, 2019·Bipolar Disorders·Alain Braillon, Françoise Taiebi
Sep 17, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·S A StrejilevichM R Goldfarb
Apr 22, 2020·The American Journal of Psychiatry·Taeho Greg RheeSamuel T Wilkinson
Jul 11, 2020·Bipolar Disorders·Ole Köhler-ForsbergSøren D Østergaard
Mar 28, 2020·The International Journal of Pharmacy Practice·Kathleen RyanJanine Traulsen
Sep 27, 2020·Bipolar Disorders·Joel WinstanleySameer Jauhar
Jul 13, 2020·Psychiatry Research·Gianluca SerafiniMario Amore
Mar 10, 2021·International Journal of Bipolar Disorders·Xabier Pérez de MendiolaAna González-Pinto

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