Changes in presumed motor cortical activity during fatiguing muscle contraction in humans

Acta Physiologica
T Seifert, Nicolas T Petersen

Abstract

Changes in sensory information from active muscles accompany fatiguing exercise and the force-generating capacity deteriorates. The central motor commands therefore must adjust depending on the task performed. Muscle potentials evoked by transcranial magnetic stimulation (TMS) change during the course of fatiguing muscle activity, which demonstrates activity changes in cortical or spinal networks during fatiguing exercise. Here, we investigate cortical mechanisms that are actively involved in driving the contracting muscles. During a sustained submaximal contraction (30% of maximal voluntary contraction) of the elbow flexor muscles we applied TMS over the motor cortex. At an intensity below motor threshold, TMS reduced the ongoing muscle activity in biceps brachii. This reduction appears as a suppression at short latency of the stimulus-triggered average of rectified electromyographic (EMG) activity. The magnitude of the suppression was evaluated relative to the mean EMG activity during the 50 ms prior to the cortical stimulus. During the first 2 min of the fatiguing muscle contraction the suppression was 10 +/- 0.9% of the ongoing EMG activity. At 2 min prior to task failure the suppression had reached 16 +/- 2.1%. In control ...Continue Reading

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Citations

Mar 26, 2013·Experimental Brain Research·Benedikt LauberWolfgang Taube
Mar 22, 2012·European Journal of Applied Physiology·K N MilevaJ L Bowtell
Jan 10, 2012·Acta Physiologica·P Bie
May 23, 2012·Acta Physiologica·J Henriksson
Oct 25, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gabrielle ToddKemal S Türker
Dec 1, 2015·Experimental Gerontology·Selma PapegaaijTibor Hortobágyi
Oct 8, 2016·Scandinavian Journal of Medicine & Science in Sports·T K KhongA Yusof

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