Changes in presynaptic protein NACP/alpha-synuclein in an ischemic gerbil hippocampus

Brain Research
H IshimaruY Maruyama

Abstract

We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP-positive unusual tubal and chain-like structures developed on month 6. We suggest that the changes in NACP may play an important role in the ischemic pathogenesis.

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Citations

Apr 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·M ShojiS Hirai
Jan 30, 2008·Neuroscience Letters·Mikhail Y Golovko, Eric J Murphy
Dec 19, 2014·Brain Pathology·Seth Love, J Scott Miners
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