Changes in prevalence of prescription opioid abuse after introduction of an abuse-deterrent opioid formulation

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Theresa A CassidyStephen F Butler

Abstract

The reformulation of oxycodone hydrochloride controlled-release (CR) tablets in August 2010 created a natural experiment at a national scale, providing an opportunity to evaluate patterns of abuse of prescription opioids and other drugs before and after introduction of this abuse-deterrent formulation (ADF). Observational, cross-sectional study Sentinel sample of adults assessed for substance abuse treatment within the NAVIPPRO® surveillance system Two hundred thirty-two thousand and eight hundred seventy-four adults at 437 facilities during January 1, 2008 through December 31, 2011. Time-series analysis using logistic regression to estimate quarterly prevalence of past 30-day abuse (adjusted for covariates and prescription volume) and changes in abuse pre-and post-ADF introduction. Increases in abuse prevalence occurred for all prescription opioids as a class and for extended-release (ER) opioids. Significantly greater abuse of ER oxymorphone and buprenorphine occurred in the post-ADF period (relative risk [RR] = 2.91, 95% confidence interval [CI] = 2.59-3.27 and RR = 1.85, 95% CI = 1.74-1.96). Increases in abuse for these two compounds were significant among groups who reported abuse via preferential routes of administration ...Continue Reading

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Citations

Jul 7, 2015·Drug Development and Industrial Pharmacy·Tiffani D EisenhauerThomas Barrett
Jul 22, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Noam Y KirsonEdward Michna
Aug 26, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Daniel P AlfordJulie L White
Jan 14, 2016·The New England Journal of Medicine·Wilson M ComptonGrant T Baldwin
Dec 15, 2015·Drug and Alcohol Dependence·Joseph J PalamarDanielle C Ompad
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Oct 11, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Stephen F ButlerAlison B Fleming
Apr 3, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lynn R WebsterStefan Aigner
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Jan 30, 2020·Preventive Medicine Reports·Rosanna SmartBradley D Stein

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