PMID: 6108750Dec 1, 1980Paper

Changes in prevalence, severity, and recovery in tardive dyskinesia with age

Archives of General Psychiatry
J M Smith, R J Baldessarini

Abstract

Advancing age is one of the few factors suggested to predict increased risk of tardive dyskinesias (TDs). By pooling and reanalyzing available epidemiological data, we found strong linear correlations between ages (< 40 to 70 years) and both the prevalences and severity of TD, while neither increased significantly after age 70 years. There was also a strong inverse correlation between rates of spontaneous remission of TD and age (< 30 to > 80 years); TD in those younger than 60 years improved over three times as often as in older patients. These correlations are not readily explained by the duration of previous exposure to neuroleptic drugs and may reflect increased sensitivity of the aging brain to them. These observations support caution in the prolonged use of neuroleptics in patients older than age 50 years but encourage optimism for eventual spontaneous remission of TD in young adults.

Citations

Dec 7, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Leslie J CloudStewart A Factor
Mar 10, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Jack J Chen, Kelly C Lee
May 30, 2013·BMC Psychiatry·Ray M MerrillPaul M Matiaco
Nov 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J BlinY Agid
Dec 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·J M GaioJ Perret
Jun 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·T R BarnesT Trauer
May 1, 1984·Postgraduate Medical Journal·T R Barnes, W M Braude
Feb 18, 1984·British Medical Journal·B E WiholmJ E Häggström
Jan 16, 1998·European Journal of Pharmacology·A N SussmanJ L Neisewander
May 1, 1988·Irish Journal of Medical Science·J L Waddington
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Wolfarth, K Ossowska
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·R Yassa, V Nair
Jun 17, 2003·Journal of the American Medical Directors Association·Richard J Goldberg
Jun 17, 2003·Journal of the American Medical Directors Association·Richard J Goldberg
Oct 30, 1998·Journal of Psychiatric Research·D V JesteM P Caligiuri
Jul 1, 1989·Psychiatry Research·S MukherjeeD B Schnur
Apr 1, 1987·Biological Psychiatry·W F HoffmanD E Casey
Jan 1, 1981·Progress in Neuro-psychopharmacology·E G McGeer
Jan 1, 1981·Psychopharmacology·A Campbell, R J Baldessarini
Jan 1, 1982·Psychopharmacology·D E CaseyN Bjørndal
Nov 30, 2000·Current Treatment Options in Neurology·D Tarsy
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·G T Barthalmus, K B Meadows
May 1, 1991·The International Journal of Neuroscience·R Sandyk, S R Kay
Dec 1, 1991·The International Journal of Neuroscience·R SandykR P Iacono
Sep 24, 2015·The International Journal of Neuroscience·Zhiyu LvZuoxiao Li
Jan 11, 2005·Journal of the American Pharmacists Association : JAPhA·Douglas ShafferAnn Corken Mackey
Jun 1, 1994·Chest·M W Rich, S M Radwany
Sep 1, 1985·Journal of Gerontological Nursing·V F EngleL Bobel
Aug 1, 1990·Journal of Gerontological Nursing·L B Taft, R L Barkin
Nov 16, 2004·Journal of the American Geriatrics Society·Richard M Trosch
Jan 1, 1987·Journal of Chronic Diseases·H MorgensternS Holmberg
Feb 1, 1983·Journal of the American Geriatrics Society·M A Jenike
Mar 1, 1987·Journal of the American Geriatrics Society·C A PeabodyL E Hollister
Mar 1, 1986·New Directions for Mental Health Services·T Howell, R J Diamond
Jul 17, 1998·Neurologic Clinics·K Kompoliti, C G Goetz
Mar 1, 2005·The Psychiatric Clinics of North America·Perminder S Sachdev
Nov 1, 1986·Biological Psychiatry·R YassaG Schwartz

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