Changes in pro-inflammatory cytokine levels and late-life depression: A two year population based longitudinal study.

Psychoneuroendocrinology
Jae-Min KimJin-Sang Yoon

Abstract

Longitudinal associations of cytokine levels with depression are unclear. This study aimed to investigate cross-sectional and prospective associations between five serum pro-inflammatory cytokine levels and late-life depression. 732 Korean people aged 65+ were evaluated at baseline. Of 631 without depression (Geriatric Mental State schedule) at baseline, 521 (83%) were followed over a 2 year period and incident depression was ascertained. Serum tumor necrosis factor-α, interleukin (IL)-1α, IL-1β, IL-6, and IL-8 levels were assayed at both baseline and follow-up. Associations between cytokine levels and depressive status were evaluated using linear regression models, considering potential covariates (demographics, cognitive function, disability, lifestyle factors, and vascular risk factors) and applying Bonferroni corrections. Prevalent depression at baseline was significantly associated with higher contemporaneous levels of IL-1β and IL-8, independent of relevant covariates and after applying Bonferroni corrections. In the analyses of the five cytokine levels in combination, independent associations were found between prevalent depression and increased numbers of cytokines at higher levels at baseline. Incident depression was s...Continue Reading

Citations

Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Maria LucaAntonina Luca
Jun 13, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·André R BrunoniIsabela Martins Benseñor
Nov 14, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shih-Jen Tsai
Apr 19, 2021·Psychoneuroendocrinology·E Lydia WuChristopher P Fagundes
Mar 27, 2021·The European Journal of Neuroscience·Jasmin ObermannsBarbara Emons
Jul 25, 2021·International Journal of Molecular Sciences·Chien-Yi KuoHsien-Yuan Lane

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