PMID: 9430607Jan 31, 1998Paper

Changes in production of ethanol, acids and H2 from glucose by the fecal flora of a 16- to 158-d-old breast-fed infant

The Journal of Nutrition
M J WolinS Bank

Abstract

Microbes in the adult human colon ferment dietary substrates chiefly to acetic, propionic and butyric acids and CO2, H2 and CH4. How this fermentation evolves after microbial colonization of the neonate is unknown. We examined the fermentation of glucose by fecal suspensions of a breast-fed infant from d 16 to 158 and found that the fermentation changed with age. Acetate, ethanol, succinate, lactate, formate and H2 were formed up to 117 d of age. Production of succinate, lactate, formate and H2 ceased after 117 d and acetate production increased. Butyrate and propionate were minor products up to 117 d. Afterwards, there was a slight increase in propionate production with no change in butyrate formation. Acetate was always the major product of glucose fermentation by the fecal suspensions. Approximately the same amounts of ethanol were formed throughout the study period. The fermentations were similar to fermentations of Escherichia coli and streptococci through 117 d. Nuclear magnetic resonance (NMR) analysis of the acetate formed from 1-13C- and 3-13C-glucose showed that the dominant fermentation pathway used by the colonic microbes switched from the Embden-Meyerhof-Parnas pathway at 16 d of age to the Bifidobacterium pathway ...Continue Reading

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Citations

Jul 14, 2009·NMR in Biomedicine·Albert A de GraafKoen Venema
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Hiroshi Sato, Yumiko Shiogama
Sep 1, 2008·Journal of Breath Research·B De Lacy CostelloS Smith
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Irene ZelnerGideon Koren
May 17, 2003·The Proceedings of the Nutrition Society·David L ToppingAnthony R Bird
Aug 1, 2014·Journal of Pediatric Gastroenterology and Nutrition·M PourcyrousR K Buddington

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