PMID: 16508389Mar 2, 2006Paper

Changes in properties of substantia gelatinosa neurons after surgical incision in the rat: in vivo patch-clamp analysis

Anesthesiology
Mikito KawamataAkiyoshi Namiki

Abstract

Noxious information through A delta and C afferent fibers is transmitted to substantia gelatinosa, a process that plays an important role in plastic changes of nociceptive processing in pathophysiological conditions. In this study, changes in properties of substantia gelatinosa neurons and their sensitivity to systemic administration of lidocaine after surgical incision were investigated using the in vivo patch-clamp technique. Under urethane anesthesia, in the current clamp mode, spontaneous activities and responses of substantia gelatinosa neurons to nonnoxious air-puff stimuli and noxious pinch stimuli were recorded before and after 1-cm-long incisions had been made in hairy skin of the hindquarters of rats. Systemic administration of lidocaine (2 mg/kg) was applied at 30 min after the incision. Stable recordings for 30 min or more after the incision were obtained from 18 substantia gelatinosa neurons that were classified as multireceptive (n = 8), nociceptive (n = 5), and subthreshold (n = 5) neurons. Action potential firing disappeared immediately after completion of the wound closure in most multireceptive and nociceptive neurons, and sustained spontaneous action potential firing was observed in 23% of these substantia ge...Continue Reading

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Citations

Apr 26, 2007·Anesthesia and Analgesia·Yi ZhangJames M Sonner
Jan 13, 2016·Anesthesia and Analgesia·Tao HuTao Liu

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