PMID: 1208887Dec 1, 1975Paper

Changes in prostaglandin concentration in blood subjected to repetitive freezing and thawing

Prostaglandins
M B Waitzman, M L Law

Abstract

Successive freezing and thawing of whole blood results in a consistently higher yield of various prostaglandin (PG) compounds. Evaluations were made with radioimmunological assay. The increase in PG concentrations seems to be more associated with cell fragmentation and not with the dissociation of albumin-PG complex. Our data suggest that there may be some dissociation of non-albumin-PG complexes. Artifactually high PG concentrations due to in vitro PG synthetase activity appears minimal at least with respect to indomethacin blocking of this enzyme. There are, in general, only slight differences in PG concentrations in samples with and without indomethacin.

References

Aug 1, 1975·Prostaglandins·R T JacksonS E Nathanson
Jun 1, 1972·The Journal of Pharmacy and Pharmacology·W G Unger
Apr 10, 1974·Prostaglandins·J M GoodsonA Brunetti
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·E M GlennB J Bowman
Jan 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·M W Greaves, W McDonald-Gibson
Jun 1, 1972·Prostaglandins·M J SilverJ J Kocsis
Aug 10, 1973·Experimental Eye Research·M B Waitzman
Jan 10, 1974·Prostaglandins·S K Saksena, V D Castracane
Apr 10, 1974·Prostaglandins·W StylosR Skarnes
Oct 1, 1971·Nature·W G UngerA Bennett
May 26, 1972·Biochemical and Biophysical Research Communications·L LevineA H Tashjian

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Citations

May 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A OguoghoH Sinzinger
Aug 1, 1978·Prostaglandins and Medicine·M B Waitzman, D Rudman
Jun 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A NellH Sinzinger

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