Changes in psychotropic prescription medication use and their relationship with mortality among people with traumatic spinal cord injury

Spinal Cord
Yue CaoJames S Krause

Abstract

Prospective cohort study. To identify the relationship of frequency of prescription medication use to treat pain, spasticity, sleep, and depression/stress, and change in prescription medication use with risk of all-cause mortality. This study was initiated at a specialty hospital in the Southeastern USA, with follow-up and data analysis at an academic medical center in the Southeastern United States. Prospective data were collected in 1997-1998 (Time 1) and 2007-2009 (Time 2), with mortality determined as of 31 December 2014. The initial participant cohort was comprised of 1386 participants with traumatic SCI who were adults and a minimum of 1-year post-injury at enrollment in 1997-1998. Of these, 863 participated at follow-up and 861 were included in the current mortality analysis. The frequency of taking prescription medication increased over the 10-year timeframe, particularly for sleep and pain. Each type of prescription medication at Time 1 was associated with later mortality, and an increase in medication use over time was associated with a greater risk of mortality for three of the four conditions (all except spasticity). A decrease in the frequency of pain medication use over time was associated with a decreased risk of...Continue Reading

References

Jun 1, 1993·Journal of Health and Social Behavior·R J Johnson, F D Wolinsky
Sep 1, 1996·Journal of Clinical Epidemiology·J C HaysD T Gold
Mar 1, 1997·Journal of Health and Social Behavior·E L Idler, Y Benyamini
Oct 31, 1997·Journal of Health and Social Behavior·M M Farmer, K F Ferraro
Jan 12, 1999·American Journal of Epidemiology·D L McGeeR S Cooper
Aug 15, 2003·Archives of Physical Medicine and Rehabilitation·Mary Ann McCollHans Frankel
May 1, 2007·Archives of Physical Medicine and Rehabilitation·Mark P JensenDiane D Cardenas
Jan 22, 2009·Archives of Physical Medicine and Rehabilitation·James S KrauseElisabeth Pickelsimer
Oct 6, 2009·Archives of Physical Medicine and Rehabilitation·James S KrauseRickey E Carter
Oct 29, 2011·Archives of Physical Medicine and Rehabilitation·James S Krause, Lee L Saunders
Feb 1, 2012·Archives of Physical Medicine and Rehabilitation·Lee L Saunders, James S Krause
Mar 27, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Andrew I GellerDale C Strasser
Apr 13, 2012·Archives of Physical Medicine and Rehabilitation·Lee L SaundersJoshua Acuna
Jun 28, 2014·The Journal of Spinal Cord Medicine·Patrick KitzmanJimmi Hatton Kolpek
Oct 9, 2015·The Journal of Spinal Cord Medicine·Tejal PatelJoseph Lee
Jun 1, 2015·Drugs -- Real World Outcomes·Børge SivertsenSimon Øverland

❮ Previous
Next ❯

Citations

May 1, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Mohsen BazarganShervin Assari
Nov 24, 2020·Archives of Physical Medicine and Rehabilitation·Nicole D DiPiroJames S Krause

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.