Changes in pulmonary artery pressure during the acute phase of respiratory distress syndrome treated with three different types of surfactant

Pediatric Pulmonology
A H Hamdan, N J Shaw

Abstract

We studied the changes in acceleration time/right ventricular ejection time ratio (AT/RVET; indicative of changes in pulmonary artery pressure) calculated from Doppler ultrasound examinations performed before and 1, 6, and 12 h after the first and second doses of surfactant following the administration of each of three different surfactants during the acute phase of the respiratory distress syndrome. Maximum fractional inspired oxygen concentration (F(I,O2)) and peak inspiratory pressure (PIP) were recorded during each 4 h period from birth for the first 24 h and subsequently every 24 h until 72 h. Eighty-three infants were studied. Fifty patients weighing > 1 kg received Exosurf (n = 29) or ALEC (n = 21) and 33 weighing < or = 1 kg received Exosurf (n = 22) or Survanta (n = 11). The AT/RVET rose rapidly after administration of all three surfactants. There was no significant difference in the change in AT/RVET between those > 1 kg who received Exosurf and those who received ALEC (a synthetic surfactant). Similarly, there was no difference between those infants < or = 1 kg who received Exosurf and those who received Survanta. The F(I,O2) requirements, but not PIP, were lower in those infants who received Survanta at 12 and 20 h ...Continue Reading

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Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Sean B Ainsworth, David W A Milligan
Feb 26, 2004·Paediatric Respiratory Reviews·Colin Morley, Peter Davis
Sep 26, 2001·Clinics in Perinatology·G K Suresh, R F Soll
Apr 27, 2010·American Journal of Obstetrics and Gynecology·Humberto AzpuruaStephen F Thung
Oct 4, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohamed LabanAbdelrahman Saleh

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