Changes in Pulmonary Function and Controlled Ventilation-High Resolution CT of Chest After Antibiotic Therapy in Infants and Young Children with Cystic Fibrosis

Lung
Shahid I SheikhK McCoy

Abstract

Infants with cystic fibrosis (CF) develop early progressive lung disease which may be asymptomatic. Infant pulmonary function tests (IPFT) and controlled ventilation-high resolution computed tomography (CV-HRCT) of chest can detect early asymptomatic lung disease. It is not well established that these objective measures can detect changes in lung disease after clinical interventions. The purpose of this study was to evaluate usefulness of IPFT and CV-HRCT to detect changes in lung disease after intravenous (IV) antibiotic therapy in infants with early CF-related lung disease. IPFTs and CV-HRCT done before and after 2 weeks of IV antibiotics in infants at our institution over the last 12 years were compared. CV-HRCTs were compared using the modified Brody scoring system. The sample included 21 infants, mean age 85.2 ± 47.6 weeks. Mean change in weight was 0.4 ± 0.38 kg (p = 0.001). Significant changes in IPFT included mean % predicted FEV(0.5) (+13.5 %, p = 0.043), mean %FEF(25-75) (+30.2 %, p = 0.008), mean %RV/TLC (-11.2 %, p = 0.008), and mean %FRC/TLC (-4.5 %, p = 0.001). Total Brody scores improved from a median of 10 to 5 (p < 0.001) as did mean scores for airway wall thickening (p = 0.050), air trapping (p < 0.001), and p...Continue Reading

References

Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·M JonesR S Tepper
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May 4, 2001·The European Respiratory Journal·J StocksUNKNOWN ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Soci
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Mar 15, 2011·Thorax·Sarath C RanganathanUNKNOWN Australian Respiratory Early Surveillance Team for Cystic Fibrosis
Apr 16, 2011·American Journal of Respiratory and Critical Care Medicine·Naveen PillarisettiUNKNOWN Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF)
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May 23, 2013·The New England Journal of Medicine·Peter D SlyUNKNOWN AREST CF Investigators
Oct 18, 2013·Thorax·Lena P ThiaUNKNOWN London Cystic Fibrosis Collaboration

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Citations

May 19, 2017·Respiratory Research·Magdalena KołodziejBruce R Thompson
Apr 15, 2016·The European Respiratory Journal·Wieying KuoUNKNOWN ECFS-CTN/SCIFI CF study group
May 28, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Rebecca J DarrahFrank J Jacono

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