Changes in Pulmonary Function Following Image-Guided Stereotactic Lung Radiotherapy: Neither Lower Baseline Nor Post-SBRT Pulmonary Function Are Associated with Worse Overall Survival

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Brandon StoneInga S Grills

Abstract

To determine changes in pulmonary function brought about by lung stereotactic body radiation therapy (SBRT). One hundred and twenty-seven patients were treated with lung SBRT using 48 to 60Gy in four to five fractions on a prospective trial. We obtained pulmonary function tests (PFTs) at baseline, 6 weeks, 3 months, 6 months, 9 months, 12 months, and 24 months after SBRT. Group mean PFT parameter values are reported. At baseline forced expiratory volume in 1 second (FEV1) was 1.5 l (67% predicted, range: 0.4-3.4 l), corrected diffusing capacity for carbon monoxide was 12.2 ml/min/mmHg (50.8% predicted, range: 3.3-27.2 ml/min/mmHg), and total lung capacity was 5.7 l (102.4% predicted, range: 3.1-9.1 l). At 12 months, there was decline in FEV1 (-4.1%; p = 0.01), corrected diffusing capacity for carbon monoxide (-5.2%; p = 0.027), forced vital capacity (-5.7%; p = 0.004), and total lung capacity (-3.6%; p = 0.039). Declines in FEV1 (-7.6%; p = 0.001) and forced vital capacity (-8.9%; p = 0.001) persisted at 24 months. Rates of pneumonitis were 3.1% and 0.8% for grades 2 and 3, respectively. There were no grade 3 PFT toxicities at 12 months. Lower PFTs at baseline and 1 year after SBRT did not predict for worse overall survival. As...Continue Reading

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Citations

Apr 23, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Arturo Navarro-MartinFerran Guedea
Oct 27, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Anne Charloux, Elisabeth Quoix
Sep 22, 2016·Journal of Medical Imaging and Radiation Oncology·Raphael JumeauCatherine Beigelman-Aubry
Mar 7, 2021·Cancers·Alexandre DelplaLambros Tselikas

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