Changes in quality-of-life and psychosocial adjustment among multiple myeloma patients treated with high-dose melphalan and autologous stem cell transplantation

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Allen C ShermanElias J Anaissie

Abstract

High-dose melphalan and autologous hematopoietic stem cell transplantation (HSCT) is a standard treatment for myeloma, but very little is known about the psychosocial or quality-of-life difficulties that these patients encounter during treatment. Data regarding older patients is particularly scarce. Using a prospective design, this investigation evaluated 94 patients at stem cell collection and again after high-dose therapy and transplantation. Outcomes included quality-of-life (FACT-BMT) and psychosocial adjustment (ie, Brief Symptom Inventory, Impact of Events Scale, and Satisfaction with Life Scale). Findings were compared with age- and sex-adjusted population norms and with transplantation patient norms. At stem cell collection, physical deficits were common, with most patients scoring 1 standard deviation below population norms for physical well-being (70.2%) and functional well-being (57.5%), and many reporting at least moderate fatigue (94.7%) and pain (39.4%). Clinically meaningful levels of anxiety (39.4%), depression (40.4%), and cancer-related distress (37.0%) were evident in a notable proportion of patients. After transplantation, there was a worsening of transplant-related concerns (P < .05), depression (P < .05), ...Continue Reading

References

May 1, 1979·Psychosomatic Medicine·M HorowitzW Alvarez
Nov 1, 1984·Journal of Personality and Social Psychology·E Diener, R A Emmons
May 9, 2003·The New England Journal of Medicine·J Anthony ChildUNKNOWN Medical Research Council Adult Leukaemia Working Party
Jun 27, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Allen C ShermanElias J Anaissie
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Choon-Kee LeeGuido Tricot
Jan 19, 2005·European Journal of Haematology·C A Uyl-de GrootP C Huijgens
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A AndrykowskiJohn R Wingard
Apr 27, 2005·Evaluation & the Health Professions·Penny S BruckerDavid Cella
Oct 7, 2005·Psycho-oncology·Sean RansomMargaret Booth-Jones
Nov 1, 2005·Cancer·Frank BakerMichele M West
Feb 1, 1985·Journal of Personality Assessment·E DienerS Griffin
Mar 10, 2006·The New England Journal of Medicine·Bart BarlogieJohn Crowley
Oct 17, 2006·Bone Marrow Transplantation·E Jantunen
Apr 18, 2007·Bone Marrow Transplantation·K O AndersonC S Cleeland
Feb 9, 2008·Cancer·Erica CampagnaroKaren O Anderson
Oct 16, 2008·Journal of Behavioral Medicine·Allen C ShermanElias J Anaissie

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Citations

Dec 10, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alex MolassiotisJames Cavet
Oct 12, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Melinda CraikePatricia M Livingston
Oct 31, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Janet Sirilla, Janine Overcash
Oct 16, 2008·Journal of Behavioral Medicine·Allen C ShermanElias J Anaissie
Nov 16, 2011·International Journal of Hematology·Sarah Jayne LiptrottGiovanni Martinelli
Dec 1, 2010·Cancer Nursing·Eileen Danaher HackerLisa Gaston
Feb 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Chelsea G RatcliffLorenzo Cohen
Dec 22, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Annemarie M J BraamseKaren L Syrjala
Mar 29, 2014·European Journal of Haematology·Annemieke LeunisBob Löwenberg
Apr 22, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Heather S L JimOxana Palesh
Feb 25, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·R BazP Richardson
May 15, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Amir SteinbergJack B Fu
Nov 6, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·James R BerensonRobert Vescio
Mar 17, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Deidre B PereiraVijay S Reddy
Nov 28, 2013·Clinical Journal of Oncology Nursing·Sandra KurtinJacy Spong
Jun 2, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alix E HallH Sharon Campbell
Oct 21, 2016·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Janet ShuVaishali Sanchorawala
Aug 17, 2016·European Journal of Haematology·Christina RamsenthalerIrene J Higginson
Apr 11, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sam H AhmedzaiUNKNOWN National Cancer Research Institute Haemato-Oncology Clinical Studies Group
Jun 25, 2014·Palliative & Supportive Care·James ZaboraIrene M Ghobrial
Jun 30, 2019·Expert Review of Hematology·Massimo MartinoMassimo Gentile

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