Changes in quality of life in patients with osteoarthritis treated with celecoxib: the Qualice study

La Presse médicale
Sylvie RozenbergYasmine Jeanpetit

Abstract

Evaluation of patients with osteoarthritis includes the assessment of pain, functional disability, and radiographically-detectable lesions. The physical and psychological consequences of this disease on patients' quality of life are not clearly understood. The aim of this study was to determine the changes in quality of life among osteoarthritis patients after celecoxib treatment. The SF-36 Quality of Life questionnaire was used in this prospective multicenter study to evaluate changes in pain intensity and quality of life in 2339 patients with osteoarthritis treated by 1244 general practitioners with celecoxib (200 mg per day) for 4 weeks. Pain intensity was measured with a visual analogue scale. The suitability of the SF-36 for such an evaluation was also studied, as was tolerance of the medication. After 4 weeks of celecoxib treatment, 8 of the 9 domains of the SF-36 questionnaire showed significant improvement, with an effect size > 0.40, especially for "limitations due to physical health" and "limitations due to pain". Pain intensity decreased from 66.5+/-12.2 mm at inclusion to 34.0+/-18.7 mm at the final visit. Both patients and physicians found the questionnaire suitable for assessing the quality of life of osteoarthrit...Continue Reading

References

Jun 18, 2002·BMJ : British Medical Journal·Andrew GarrattRay Fitzpatrick
Jan 15, 2005·Journal of Clinical Epidemiology·Anne-Christine RatFrancis Guillemin
Jul 27, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Johanna M van der WaalJoost Dekker

❮ Previous
Next ❯

Citations

May 23, 2017·The Cochrane Database of Systematic Reviews·Livia PuljakPeter Tugwell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved