Changes in quantitative bone histomorphometry in aging healthy men

The Journal of Clinical Endocrinology and Metabolism
B L ClarkeL A Fitzpatrick

Abstract

Changes in bone mineral metabolism with aging in healthy men and the roles of various factors in the pathogenesis of age-related changes in quantitative bone histomorphometry in men are poorly defined. To clarify these changes and factors, serum and urinary biochemical parameters and iliac crest bone biopsies were evaluated in 43 healthy men, aged 20-80 yr. The static histomorphometric parameters, cancellous bone volume and osteoblast-osteoid interface, decreased by 40.0% and 19.2%, respectively, between 20-80 yr of age. The dynamic histomorphometric parameters, double and single labeled osteoid, also decreased by 18.6% and 18.0%, respectively, over this period. None of the other static or dynamic histomorphometric parameters changed with age in this population sample of healthy men. Univariate analysis of static bone histomorphometric parameters and biochemical parameters revealed significant correlations between osteoid surface and intact PTH (r = 0.37; P = 0.015); osteoclast surface and serum total testosterone (r = 0.36; P = 0.016), estradiol (r = 0.40; P = 0.009), and FSH (r = 0.49; P = 0.001); osteoblast-osteoid interface and serum phosphate (r = 0.31; P = 0.046); and cortical thickness and serum total calcium (r = 0.38; ...Continue Reading

Citations

May 30, 2008·Calcified Tissue International·Matthew J Silva, Michael D Brodt
Apr 21, 2010·Calcified Tissue International·Mark D WillinghammMatthew J Silva
Sep 27, 2000·Annals of the Rheumatic Diseases·J M KaufmanJ Y Reginster
Apr 18, 2001·The Journal of Clinical Investigation·M P MaciasN A Lee
May 29, 2008·The Journal of Clinical Endocrinology and Metabolism·Eric P SmithKenneth S Korach
Mar 15, 2014·Disease Models & Mechanisms·Tracy A BrennanRobert J Pignolo
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matthew J SilvaYousef Abu-Amer
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jordan L GellerMichael T Collins
Jul 20, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaodong LiHua Zhu Ke
Apr 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rachel I GafniMichael T Collins
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R G ErbenM Goldberg
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark S CooperPaul M Stewart
Jul 5, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mishaela R RubinJohn P Bilezikian
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maureen M J GuichelaarJ Eileen Hay
Sep 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E ShaneT L Clemens

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