Changes in RANTES and beta-thromboglobulin after intensive exercise in patients with allergic asthma

International Archives of Allergy and Immunology
Ziemowit ZietkowskiMaciej Szmitkowski

Abstract

There is increasing evidence that exercise-induced bronchoconstriction (EIB) is associated with eosinophilic airway inflammation. In the pathogenesis of EIB the role of chemokines - responsible for promoting the migration and activation of inflammatory cells - as well as blood platelets, a potential source of those chemokines, remains unclear. The study was conducted in a group of 19 asthmatics (11 with EIB, 8 without EIB) and 8 healthy volunteers. Changes in the plasma concentrations of RANTES and beta-thromboglobulin (beta-TG) induced by intensive exercise were determined. Moreover, the possible correlation of these measurements with the results of other tests used in the diagnosis of asthma as well as laboratory tests commonly associated with asthma were investigated. A comparison of the concentrations of beta-TG in all groups studied at rest did not reveal any significant differences. In all groups studied, 30 min after exercise elevated beta-TG concentrations were observed; the most significant increase was revealed in asthmatics with EIB. The baseline concentrations of RANTES before exercise in both groups of asthmatics were significantly higher in comparison to the group of healthy volunteers. After exercise, in the grou...Continue Reading

Citations

Oct 10, 2009·Current Allergy and Asthma Reports·Chris Randolph
Oct 12, 2010·Journal of Physiology and Biochemistry·Juan José GarcíaEduardo Ortega
Nov 5, 2014·Journal of the American Geriatrics Society·Gwendolyn A SowaDebra Weiner
Dec 27, 2015·Allergy·Ulrich M ZisslerCarsten B Schmidt-Weber
Oct 28, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marcin MoniuszkoMilena Dabrowska
May 9, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Margaret M KuderSharmilee M Nyenhuis

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