Changes in Redox Signaling in the Skeletal Muscle with Aging

Oxidative Medicine and Cellular Longevity
Péter SzentesiAnikó Keller-Pintér

Abstract

Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and intrinsic force production (quality). Along with decreased functional capacity of the muscle, age-related muscle loss is associated with corresponding comorbidities and healthcare costs. Mitochondrial dysfunction and increased oxidative stress are the central driving forces for age-related skeletal muscle abnormalities. The increased oxidative stress in the aged muscle can lead to altered excitation-contraction coupling and calcium homeostasis. Furthermore, apoptosis-mediated fiber loss, atrophy of the remaining fibers, dysfunction of the satellite cells (muscle stem cells), and concomitant impaired muscle regeneration are also the consequences of increased oxidative stress, leading to a decrease in muscle mass, strength, and function of the aged muscle. Here we summarize the possible effects of oxidative stress in the aged muscle and the benefits of physical activity and antioxidant therapy.

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Citations

Sep 18, 2020·PloS One·Alex W SteilJennifer C Klein
Jan 30, 2020·Cells·Alessandra StacchiottiLuigi Fabrizio Rodella
Dec 10, 2019·Oxidative Medicine and Cellular Longevity·Mónika SztretyeAnikó Keller-Pintér
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Dec 7, 2021·Journal of Cachexia, Sarcopenia and Muscle·Cyriel Sebastiaan OlieVered Raz
Jan 15, 2022·The FEBS Journal·Korin SahinyanVahab D Soleimani

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Methods Mentioned

BETA
biopsies

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