Changes in regional cerebral blood flow in the right cortex homologous to left language areas are directly affected by left hemispheric damage in aphasic stroke patients: evaluation by Tc-ECD SPECT and novel analytic software

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
G UrumaM Abo

Abstract

The objective of this study was to clarify the influence of regional cerebral blood flow (rCBF) changes in language-relevant areas of the dominant hemisphere on rCBF in each region in the non-dominant hemisphere in post-stroke aphasic patients. The study subjects were 27 aphasic patients who suffered their first symptomatic stroke in the left hemisphere. In each subject, we measured rCBF by means of 99mTc-ethylcysteinate dimmer single photon emission computed tomography (SPECT). The SPECT images were analyzed by the statistical imaging analysis programs easy Z-score Imaging System (eZIS) and voxel-based stereotactic extraction estimation (vbSEE). Segmented into Brodmann Area (BA) levels, Regions of Interest (ROIs) were set in language-relevant areas bilaterally, and changes in the relative rCBF as average negative and positive Z-values were computed fully automatically. To assess the relationship between rCBF changes of each ROIs in the left and right hemispheres, the Spearman ranked correlation analysis and stepwise multiple regression analysis were applied. Globally, a negative and asymmetric influence of rCBF changes in the language-relevant areas of the dominant hemisphere on the right hemisphere was found. The rCBF decreas...Continue Reading

References

Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H KarbeW D Heiss
Apr 3, 1999·Stroke; a Journal of Cerebral Circulation·K R ThulbornM A Just
Aug 26, 2000·Brain : a Journal of Neurology·T OhnishiM Sasaki
Aug 12, 2004·Neuroreport·Masahiro AboKyozo Yonemoto
Mar 16, 2005·Brain and Language·Margaret A NaeserAlvaro Pascual-Leone
Apr 28, 2006·Brain : a Journal of Neurology·Dorothee SaurCornelius Weiller
Jun 8, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alexander ThielWolf-Dieter Heiss
Jan 26, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M AboN Kaito
Mar 24, 2007·Annals of Neurology·Hiroshi YamauchiShinya Kagawa
Apr 18, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T OkamotoM Ohashi
Mar 20, 2008·Brain : a Journal of Neurology·Maria RichterThomas Straube

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Citations

May 23, 2012·Journal of the Neurological Sciences·Nobutoshi MorimotoKoji Abe
Mar 6, 2015·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Go UrumaMasahiro Abo

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