PMID: 1244731Jan 1, 1976

Changes in regional vascular resistance after myocardial infarction in the dog

The American Journal of Cardiology
M J Maximov, M J Brody

Abstract

The possibility that failure of vascular resistance to increase during hypotension in cardiogenic shock is a generalized phenomenon affecting many vascular beds was investigated in anesthetized dogs subjected to coronary arterial embolization. Blood flow in the carotid, mesenteric and renal vascular beds was monitored. Efferent vagus nerve stimulation, which, through bradycardia, produces hypotension of cardiac origin without myocardial damage, was associated with reflex vasoconstrictor responses in the carotid and mesenteric vascular beds; no change in resistance occurred in the renal vascular bed. In marked contrast, vasoconstriction failed to occur in any of the vascular beds in response to the hypotension produced by coronay embolization. These responses to cardiogenic shock mimicked those seen after ganglionic blockade, in which hypotension of partly cardiac origin was produced and reflex vasoconstriction blocked. The data support the previous hypothesis that myocardial infarction is associated with reflex inhibition of the reflex vasoconstrictor response to hypotension.

References

Jun 1, 1985·Journal of the American College of Cardiology·D RobertsonR M Robertson
Oct 1, 1985·The Journal of Clinical Investigation·R G Victor, A L Mark
Aug 1, 1985·Psychological Medicine·M PlaceR Nicol

Citations

May 1, 1972·Circulation·R M Gunnar, H S Loeb
Jun 1, 1974·The American Journal of Cardiology·P KezdiS N Misra
Jun 1, 1972·The American Journal of Cardiology·H G HanleyN S Skinner
Jun 1, 1972·Acta Physiologica Scandinavica·B Oberg, P Thorén
Jul 15, 1971·The New England Journal of Medicine·D L PageC A Sanders
Aug 1, 1971·Acta Physiologica Scandinavica·B Oberg, P Thorén
Dec 1, 1970·The American Journal of Cardiology·S ScheidtT Killip
Jul 1, 1971·American Heart Journal·T M GlennS L Wangensteen
Sep 1, 1952·The American Journal of Physiology·C M AGRESSW G CLARK
Mar 1, 1954·Circulation·W W SMITHA C FOX
Feb 1, 1963·The American Journal of Cardiology·L COSTANTIN

Related Concepts

Bradycardia
Vascular Resistance
Pathologic Vasoconstriction
Blood Vessel
Diastolic Blood Pressure
Mesentery
Myocardium
Regional Blood Flow
Myocardial Infarction
Kidney

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