Changes in regulatory T cells in dogs with cancer and associations with tumor type

Journal of Veterinary Internal Medicine
K O'NeillSteven Dow

Abstract

Regulatory T cells (Treg) have been shown to suppress antitumor immunity and often are increased in humans and rodents with cancer. However, Tregs have not been well studied in dogs with cancer and it is not known if certain tumor types are associated with increased Tregs. We hypothesized that Treg percentages would be increased in dogs with cancer and that Treg percentages would be higher in dogs with certain types of cancer. The percentages and numbers of Tregs and nonregulatory T cells and B cells were assessed in 34 dogs with cancer and 9 age-matched control dogs. Dogs evaluated included 14 dogs with sarcoma, 7 dogs with carcinoma, 7 dogs with lymphoma, and 6 dogs with mast cell tumor. Numbers and percentages of Tregs, CD4+, and CD8+ T cells and B cells were determined using flow cytometry and compared between control dogs and dogs with cancer. The percentage of Tregs was significantly increased overall in dogs with cancer compared with control dogs. When tumor types were compared, Treg percentages were significantly increased in dogs with carcinoma. The Treg/CD8 T cell ratio was significantly higher in dogs with cancer compared with control dogs and was also significantly increased in 2 dogs with T-cell lymphoma. Treg perc...Continue Reading

References

Jun 3, 2000·Annual Review of Immunology·E M Shevach
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M HaraK J Wood
Sep 15, 2001·Veterinary Immunology and Immunopathology·M FaldynaM Toman
Jul 3, 2002·Nature Reviews. Immunology·E M Shevach
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Udaya K LiyanageDavid C Linehan
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas W VahlenkampWayne Tompkins
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuelle ViguierLaurent Ferradini
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shuang FuJonathan S Bromberg
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomás AlvaroMiguel A Piris
Mar 11, 2005·Expert Review of Anticancer Therapy·John W Eklund, Timothy M Kuzel
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Felicita BaratelliSteven M Dubinett
Oct 8, 2005·The Journal of Clinical Investigation·Sarah E AllanMegan K Levings
Nov 26, 2005·The Journal of Clinical Investigation·Jens DannullJohannes Vieweg
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Dec 20, 2005·Cancer Immunology, Immunotherapy : CII·Dominik WolfAnna M Wolf
Dec 28, 2005·Seminars in Cancer Biology·Clare Baecher-Allan, David E Anderson
Mar 23, 2006·Annual Review of Immunology·Steven F Ziegler
Jul 25, 2006·Blood·Marc Beyer, Joachim L Schultze
Oct 20, 2006·European Journal of Immunology·Alison H BanhamElisabeth Suri-Payer
Nov 15, 2006·Immunological Reviews·François GhiringhelliLaurence Zitvogel
Nov 30, 2006·Annual Review of Immunology·Ann M LeenAaron E Foster
Jan 17, 2007·Veterinary Immunology and Immunopathology·B J BillerS W Dow
Feb 20, 2007·Current Opinion in Immunology·Helen Y Wang, Rong-Fu Wang
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria C LiuChung Lee
May 4, 2007·The Journal of Clinical Investigation·Tyler J Curiel
May 10, 2007·Cancer Immunology, Immunotherapy : CII·Richard W GriffithsRobert E Hawkins
Jun 30, 2007·Journal of Internal Medicine·B T Rouse
Aug 19, 2007·Annals of Medicine·Tobias BoppEdgar Schmitt
Oct 27, 2007·Cancer Immunology, Immunotherapy : CII·Sheraz YaqubKjetil Taskén
Nov 6, 2007·Immunological Reviews·John StaggMark J Smyth
Jun 14, 2013·Journal of Virology·Michelle M MillerMary B Tompkins

Citations

Mar 24, 2012·Veterinary Research·Johannes JungingerMarion Hewicker-Trautwein
Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Philip J Bergman
Jan 17, 2012·Veterinary Immunology and Immunopathology·J WassermanT L Papenfuss
Nov 8, 2015·The Veterinary Journal·Daniel ReganSteven Dow
Jun 18, 2011·Veterinary Immunology and Immunopathology·Ai WatabeTsuyoshi Kadosawa
Nov 26, 2010·International Immunopharmacology·Oliver A GardenFiona Cunningham
May 18, 2010·The Veterinary Clinics of North America. Small Animal Practice·Philip J Bergman
Jan 24, 2015·Veterinary Clinical Pathology·Stefano Comazzi
May 2, 2015·Journal of Veterinary Internal Medicine·K L Wycislo, T M Fan
Apr 8, 2014·Veterinary Parasitology·Kathlenn Liezbeth Oliveira SilvaValéria M F Lima
Apr 3, 2015·Cancer Immunology, Immunotherapy : CII·Erika Jensen-JarolimAkane Tanaka
Aug 9, 2016·Veterinary Immunology and Immunopathology·Maria Isabel CarvalhoFelisbina L Queiroga
Feb 13, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Mercedes García-SanchoAngel Sainz
Mar 6, 2016·Veterinary Pathology·T Veiga-Parga
Jan 28, 2017·Veterinary Pathology·A MarcinowskaJ Dobson
Feb 5, 2020·Frontiers in Immunology·Steven Dow
Dec 3, 2017·Journal of Veterinary Internal Medicine·J BouillonJ Lemetayer
Dec 6, 2019·Frontiers in Oncology·Douglas H Thamm
Mar 12, 2021·Advanced Drug Delivery Reviews·Lisa A Mestrinho, Ricardo R Santos

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.